ChemicalBook > CAS DataBase List > PT-2385
PT-2385
- Product Name
- PT-2385
- CAS No.
- 1672665-49-4
- Chemical Name
- PT-2385
- Synonyms
- PT-2385;CS-2108;oxy][[(1S)inden-PT2385 ，S8352;hydroxy-PT 2385;PT-2385;Benzonitrile, 3-(methylsulfonyl)
- CBNumber
- CB03041453
- Molecular Formula
- C17H12F3NO4S
- Formula Weight
- 383.34
- MOL File
- 1672665-49-4.mol
More
Less
PT-2385 Property
- Boiling point:
- 524.7±50.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);130.43(Max Conc. mM)
- pka
- 11.28±0.40(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
N-Bromosuccinimide Price
ChemScene
- Product number
- CS-4326
- Product name
- PT-2385
- Purity
- 99.59%
- Packaging
- 2mg
- Price
- $110
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0559EC
- Product name
- 3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile
- Packaging
- 1mg
- Price
- $157
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0559EC
- Product name
- 3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile
- Packaging
- 10mg
- Price
- $401
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0559EC
- Product name
- 3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile
- Packaging
- 100mg
- Price
- $1882
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN17993
- Product name
- PT-2385
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
More
Less
PT-2385 Chemical Properties,Usage,Production
Uses
PT2385 is a HIF-2α antagonist with EC50 of 27 nM in the luciferase assay, with no apparent off-target effects.
in vivo
PT-2385 (30 or 100 mg/kg; oral gavage; twice daily) result in a rapid, dose-dependent tumor regression[3].
PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1].
| Animal Model: | SCID/beige mice with the 786-O and A498 RCC cell lines[3] |
| Dosage: | 30 or 100 mg/kg |
| Administration: | Oral gavage; twice daily |
| Result: | Resulted in a rapid, dose-dependent tumor regression. |
PT-2385 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
PT-2385 Suppliers
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9126
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12476
- Advantage
- 58