2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Product Name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- CAS No.
- 1408334-75-7
- Chemical Name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Synonyms
- 4-Iodo-1H-pyrazole-1-ethanol;2-(4-iodopyrazol-1-yl)ethanol;1H-Pyrazole-1-ethanol, 4-iodo-;2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- CBNumber
- CB03042122
- Molecular Formula
- C5H7IN2O
- Formula Weight
- 238.03
- MOL File
- 1408334-75-7.mol
2-(4-Iodo-1H-pyrazol-1-yl)ethanol Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 7856DN
- Product name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Packaging
- 1g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 1408334757
- Product name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Packaging
- 1g
- Price
- $552.72
- Updated
- 2021/12/16
- Product number
- A101996
- Product name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Purity
- 98%
- Packaging
- 100mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- A101996
- Product name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- A101996
- Product name
- 2-(4-Iodo-1H-pyrazol-1-yl)ethanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
2-(4-Iodo-1H-pyrazol-1-yl)ethanol Chemical Properties,Usage,Production
Synthesis
3469-69-0
540-51-2
1408334-75-7
General procedure: preparation of 2-(4-iodo-1H-pyrazol-1-yl)ethanol 4-Iodo-1H-pyrazole (4.50 g, 23.20 mmol) was dissolved in N,N-dimethylformamide (DMF, 45 mL), and sodium hydride (60% w/w, 1.42 g, 35.5 mmol) was added at 0 °C and stirred at room temperature for 1 hour. Subsequently, 2-bromoethanol (2.5 mL, 35.2 mmol) was added dropwise to the reaction mixture at 0 °C. The reaction system was warmed up to 65 °C and stirred continuously for 3 days. Upon completion of the reaction, the reaction was quenched with saturated sodium chloride solution and ethyl acetate (EtOAc) and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using cyclohexane/ethyl acetate (0 to 50% gradient) as eluent to afford the target compound 2-(4-iodo-1H-pyrazol-1-yl)ethanol (3.55 g, 64% yield). 1H NMR (500 MHz, CDCl3): δ 7.55 (s, 1H), 7.52 (s, 1H), 4.32-4.22 (m, 2H), 4.04-3.95 (m, 2H), 2.79-2.68 (br m, 1H). LCMS (ESI) Rt = 1.50 min, MS m/z 238 [M + H]+.
References
[1] Patent: WO2014/37750, 2014, A1. Location in patent: Paragraph 00142-00144
2-(4-Iodo-1H-pyrazol-1-yl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-Iodo-1H-pyrazol-1-yl)ethanol Suppliers
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