GlyT2-IN-1

Product Name: GlyT2-IN-1
CAS No.: 448947-81-7
Chemical Name: GlyT2-IN-1
Synonyms: Yoda 1;CS-2063;GlyT2-IN-1;Yoda1 >=98% (HPLC);GlyT2-IN-1(YODA 1);Yoda 1 (GlyT2-IN-1);Yoda 1, 10 mM in DMSO;2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-
CBNumber: CB03048654
Molecular Formula: C13H8Cl2N4S2
Formula Weight: 355.27
MOL File: 448947-81-7.mol

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GlyT2-IN-1 Property

Melting point:: 136 - 138°C
Boiling point:: 538.4±60.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly)
form: powder
pka: -1.32±0.10(Predicted)
color: white to beige
InChI: 1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChIKey: BQNXBSYSQXSXPT-UHFFFAOYSA-N
SMILES: [s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl

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Safety

WGK Germany: WGK 3
HS Code: 2934999090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1558
Product name: Yoda1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1558
Product name: Yoda1
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424.65
Updated: 2025/07/31

Cayman Chemical

Product number: 21904
Product name: Yoda1
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 21904
Product name: Yoda1
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 21904
Product name: Yoda1
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

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GlyT2-IN-1 Chemical Properties,Usage,Production

Uses

Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.

Definition

ChEBI: Yoda 1 is a member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1. It has a role as a glycine transporter 2 inhibitor and a piezo1 agonist. It is an aromatic compound, a member of pyrazines, a member of thiadiazoles, an organic sulfide and a dichlorobenzene.

General Description

Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).

Biochem/physiol Actions

Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.

storage

Store at +4°C

GlyT2-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GlyT2-IN-1 Suppliers

China 108 India 1 United Kingdom 2 United States 11 Global 122

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448947-81-7, GlyT2-IN-1Related Search:

GlyT2-IN-1

Yoda 1

CS-2063

2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-

Yoda1 >=98% (HPLC)

Yoda 1 (GlyT2-IN-1)

GlyT2-IN-1(YODA 1)

2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole

KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1

Yoda 1, 10 mM in DMSO

448947-81-7

C13H8Cl2N4S2