1,4-dimethyl-5-carbethoxyimidazole

Product Name: 1,4-dimethyl-5-carbethoxyimidazole
CAS No.: 35445-32-0
Chemical Name: 1,4-dimethyl-5-carbethoxyimidazole
Synonyms: EOS-62089;1,4-dimethyl-5-carbethoxyimidazole;Ethyl 1,4-Dimethylimidazole-5-carboxylate;ethyl 3,5-dimethylimidazole-4-carboxylate;1,4-dimethyl-1H-Imidazole-5-carboxylic acid ethyl ester;1H-Imidazole-5-carboxylic acid, 1,4-dimethyl-, ethyl ester
CBNumber: CB03048881
Molecular Formula: C8H12N2O2
Formula Weight: 168.19
MOL File: 35445-32-0.mol

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1,4-dimethyl-5-carbethoxyimidazole Property

Boiling point:: 102-103 °C(Press: 0.2 Torr)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.88±0.61(Predicted)
Appearance: Colorless to light green Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E939815
Product name: Ethyl1,4-Dimethyl-1H-imidazole-5-carboxylate
Packaging: 500mg
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0370997
Product name: ETHYL-1,4-DIMETHYL-1H-IMIDAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $503.83
Updated: 2021/12/16

Ambeed

Product number: A117235
Product name: Ethyl1,4-dimethyl-1H-imidazole-5-carboxylate
Purity: 95%
Packaging: 5g
Price: $508
Updated: 2021/12/16

Chemenu

Product number: CM129718
Product name: ethyl1,4-dimethyl-1H-imidazole-5-carboxylate
Purity: 95%
Packaging: 5g
Price: $701
Updated: 2021/12/16

Alichem

Product number: 35445320
Product name: Ethyl1,4-dimethyl-1H-imidazole-5-carboxylate
Packaging: 5g
Price: $832.5
Updated: 2021/12/16

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1,4-dimethyl-5-carbethoxyimidazole Chemical Properties,Usage,Production

Synthesis

51605-32-4

74-88-4

35445-32-0

Ethyl 4-methyl-1H-imidazole-5-carboxylate (463 mg, 3.00 mmol, 1 eq.) and iodomethane (0.19 mL, 3.00 mmol, 1 eq.) were added to potassium carbonate (828 mg, 6.00 mmol, 2 eq.) in acetonitrile. The mixture was heated to reflux and stirred overnight. After completion of the reaction, it was cooled to room temperature, filtered to remove inorganic salts and the filtrate was concentrated to dryness. The crude product was purified by silica gel column chromatography (80 g silica gel) with an elution gradient of 100% EtOAc to 10% CH3OH/DCM to isolate the two regional isomers. The first eluted isomer was identified as ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate (185 mg, 1.95 mmol, 35% yield) by NOESY and HMBC NMR analysis. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 7.74 (s, 1H), 4.25 (q, J = 7.14 Hz, 2H), 3.76 (s, 3H), 2.34 (s, 3H), and 1.30 (t, J = 7.10 Hz, 3H).LC-MS (ES+) showed the molecular ion peak m/z 169.08 [M + H]+.

References

[1] Patent: WO2008/157273, 2008, A1. Location in patent: Page/Page column 86
[2] Patent: WO2004/6922, 2004, A1. Location in patent: Page/Page column 56
[3] Patent: US2004/122018, 2004, A1. Location in patent: Page 465

1,4-dimethyl-5-carbethoxyimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-dimethyl-5-carbethoxyimidazole Suppliers

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35445-32-0, 1,4-dimethyl-5-carbethoxyimidazoleRelated Search:

1,4-dimethyl-5-carbethoxyimidazole

EOS-62089

ethyl 3,5-dimethylimidazole-4-carboxylate

1,4-dimethyl-1H-Imidazole-5-carboxylic acid ethyl ester

1H-Imidazole-5-carboxylic acid, 1,4-dimethyl-, ethyl ester

Ethyl 1,4-Dimethylimidazole-5-carboxylate

35445-32-0