Larazotide

Product Name: Larazotide
CAS No.: 881851-50-9
Chemical Name: Larazotide
Synonyms: Larazotide acetate;GGVLVQPG;Larazotide acetate salt;LARAZOTIDE ACETATE (> 90%);AT-1001 (Larazotide acetate);H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH;inhibit,Larazotide acetate,Larazotide,Inhibitor,Gap Junction Protein
CBNumber: CB03054563
Molecular Formula: C34H59N9O12
Formula Weight: 785.88536
MOL File: 881851-50-9.mol

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Larazotide Property

Melting point:: >231°C (dec.)
storage temp.: Refrigerator
solubility: Water (Slightly)
form: Solid
color: White
InChIKey: NYGCNONRVCGHAT-FTIBEKKFNA-N
SMILES: C(O)(=O)C.C(O)(=O)CNC([C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(CNC(CN)=O)=O)C(C)C)CC(C)C)C(C)C)CCC(N)=O)=O |&1:10,17,21,25,29,r|

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: L175910
Product name: LarazotideAcetate(>90%)
Packaging: 25mg
Price: $640
Updated: 2021/12/16

ChemScene

Product number: CS-8047
Product name: Larazotideacetate
Purity: 99.68%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-8047
Product name: Larazotideacetate
Purity: 99.68%
Packaging: 1mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-8047
Product name: Larazotideacetate
Purity: 99.68%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-8047
Product name: Larazotideacetate
Purity: 99.68%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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Larazotide Chemical Properties,Usage,Production

Uses

Larazotide Acetate is a selective α3β4* neuronal nicotinic ACh receptor antagonist.

Biological Activity

Larazotide acetate (AT1001) is a Zonulin receptor antagonist, a tight junction modulator. Larazotide inhibition of zonulin results in reducing trafficking across epithelial cells in the intestines and reducing intestinal permeability and "leaky gut," thought to be a gateway to multiple autoimmune diseases, including celiac disease, irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD, Crohnμs and ulcerative colitis), type 1 diabetes mellitus (T1DM), nonalcoholic steatohepatitis (NASH), chronic kidney disease (CKD) and several others. It has been shown to inhibit the effect of inflammatory cytokines such as tumor necrosis factor (TNF-alpha) and interleukin (IL-4), blocking their increase of intestinal epithelial permeability.

in vivo

Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice^[1].

Animal Model:	HLA-HCD4/DQ8 double transgenic mice^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection; 250 μg twice a week for 7 weeks
Result:	Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.

Larazotide Preparation Products And Raw materials

Raw materials

Preparation Products

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Larazotide Suppliers

China 91 United States 6 Global 97

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7618
Advantage: 58

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1010
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810 18652991625;
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15781
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Nanjing YaoCheng Pharmaceutical Co., Ltd.

Tel: 025-57043319 15261831516
Fax: 025-57043319
Email: 307514552@qq.com
Country: China
ProdList: 245
Advantage: 50

Lanzhou Angeli Biochemical Technology Co., Ltd.

Tel: 0931-8235634 13321316780
Fax: +86(931) 4873122
Email: 1455540579@qq.com
Country: China
ProdList: 958
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9532
Advantage: 58

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View Lastest Price from Larazotide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Larazotide 881851-50-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Larazotide 881851-50-9
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-08

Forest chemical technology

Product: Larazotide Acetate 881851-50-9
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 1 ton/year
Release date: 2025-02-26

881851-50-9, LarazotideRelated Search:

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH

Larazotide acetate

LARAZOTIDE ACETATE (> 90%)

inhibit,Larazotide acetate,Larazotide,Inhibitor,Gap Junction Protein

Larazotide acetate salt

AT-1001 (Larazotide acetate)

GGVLVQPG

881851-50-9