Chloroacetamido-PEG4-NHS ester

Product Name: Chloroacetamido-PEG4-NHS ester
CAS No.: 1353011-95-6
Chemical Name: Chloroacetamido-PEG4-NHS ester
Synonyms: Cl-NH-PEG4-NHS;Cl-peg4-nhsester;CAS_1353011-95-6;C1-PEG4-NHS,Ester;Chloroacetamido-PEG5-NHS ester;Chloroacetamido-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate;Propanoic acid, 3-[(14-chloro-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB03059124
Molecular Formula: C17H27ClN2O9
Formula Weight: 438.86
MOL File: 1353011-95-6.mol

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Chloroacetamido-PEG4-NHS ester Property

Density: 1.31±0.1 g/cm3(Predicted)
pka: 13.57±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C292775
Product name: Chloroacetamido-PEG4-NHSEster
Packaging: 25mg
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-20519
Product name: Chloroacetamido-PEG4-NHSester
Purity: 98%
Packaging: 100mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: POL0002431
Product name: CHLOROACETAMIDO-PEG4-NHS ESTER
Purity: 95.00%
Packaging: 100MG
Price: $393.75
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1368
Product name: Chloroacetamido-PEG4- NHS ester
Packaging: 100mg
Price: $428
Updated: 2021/12/16

Matrix Scientific

Product number: 167927
Product name: Cl-peg4-nhsester
Packaging: 1g
Price: $2137
Updated: 2021/12/16

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Chloroacetamido-PEG4-NHS ester Chemical Properties,Usage,Production

Description

Chloroacetamido-PEG4-NHS ester is a PEG linker containing chloroacetamide and NHS ester functional groups. The chlorine is a good leaving group and can undergo substitution reactions. The NHS ester is an active ester which reacts with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the hydrophilic properties of the compound in aqueous media.

Uses

Chloroacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Chloroacetamido-PEG4-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloroacetamido-PEG4-NHS ester Suppliers

China 26 India 1 United Kingdom 1 United States 5 Global 33

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1353011-95-6, Chloroacetamido-PEG4-NHS esterRelated Search:

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Chloroacetamido-PEG4-NHS ester

Chloroacetamido-PEG5-NHS ester

Cl-peg4-nhsester

Cl-NH-PEG4-NHS

2,5-Dioxopyrrolidin-1-yl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate

CAS_1353011-95-6

Propanoic acid, 3-[(14-chloro-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-, 2,5-dioxo-1-pyrrolidinyl ester

C1-PEG4-NHS,Ester

1353011-95-6

C17H27ClN2O9