perampanel 3/4 hydrate

Product Name: perampanel 3/4 hydrate
CAS No.: 1571982-04-1
Chemical Name: perampanel 3/4 hydrate
Synonyms: Perampanel Hydrate;4 hydrate;perampanel 3;Perampanel 3/4H2O;perampanel 3/4 hydrate;Perampanel hydrate (4:3);3-(2-CYANOPHENYL)-1-PHENYL-5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 3/4 HYDRATE;2-(1',6'-Dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)benzonitrile hydrate (4:3)
CBNumber: CB03059139
Molecular Formula: C23H17N3O2
Formula Weight: 367.41
MOL File: 1571982-04-1.mol

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

perampanel 3/4 hydrate Chemical Properties,Usage,Production

Definition

ChEBI: Perampanel hydrate is a hydrate obtained by combining four molecules of perampanel with three molecules of water. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an AMPA receptor antagonist and an anticonvulsant. It contains a perampanel.

Clinical Use

Perampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antagonist approved for partial-onset seizures in patients with epilepsy. Perampanel was discovered and developed by Eisai.

Synthesis

A number of synthetic routes to perampanel have been reported and the process scale route is described herein.Bromination of commercial 2-methoxypyridine (120) gave 5-bromo-2-methoxypridine 121 in 86% yield (the scheme). Lithium halogen exchange was then accomplished by treating 121 with nbutyllithium followed by reaction with 2-benzenesulfonylpyridine (122) to provide bi-aryl 123 which was hydrolyzed under acidic conditions to give pyridine 124 in 60% overall yield. N-Arylation with triphenylboroxine (125) in the presence of copper acetate afforded N-aryl pyridine 126 in 91% yield. Pyridone 126 was reacted with N-bromosuccinimide to give bromopyridine 127 which was coupled with 2-(1,3,2-dioxaborinan-2-yl)benzonitrile (128) under palladium catalyzed conditions to give perampanel hydrate (XIX) in 86% yield after recrystallization from acetone/H2O.

perampanel 3/4 hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

perampanel 3/4 hydrate Suppliers

China 19 India 2 United Kingdom 1 Global 22

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@qq.com
Country: China
ProdList: 8789
Advantage: 55

Shanghai Witofly Chemical Co. ,Ltd.

Tel: 021-50630626 15821189163
Email: sales@witofly.com
Country: China
ProdList: 1605
Advantage: 55

Hunan chemfish Scientific co.,ltd

Tel: +8618229978283 19294230172
Email: sales@chemfish.com
Country: China
ProdList: 4888
Advantage: 58

Hangzhou Proserre Chemical Co.,Ltd.

Tel: +86-571-86088112
Email: info@proserre.com
Country: China
ProdList: 1077
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 18932438858
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 8355
Advantage: 58

Shanghai Taijilin Industrial Co., Ltd.

Tel: 021-021-50630626 18964684208
Fax: 021-50563898
Email: kate@tajilin.com
Country: China
ProdList: 1265
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44455
Advantage: 58

Wuhan Linglingjiu Biotechnology Co., Ltd

Tel: 15623309010
Email: 1287744812@qq.com
Country: China
ProdList: 1678
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 15870833005
Email: 2232044025@qq.com
Country: China
ProdList: 8206
Advantage: 58

Jiangsu Runfeng Synthetic Technology Co., Ltd.

Tel: 18551497631 18551497631
Email: 507167383@qq.com
Country: China
ProdList: 5026
Advantage: 58

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd

Tel: 18317105404
Email: marketing033@witofly.com
Country: China
ProdList: 2872
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 14760821013 13564957716
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29979
Advantage: 58

Wuhan Noble Pharmaceutical&Chemical Co.Ltd.

Tel: 027-87827088 13907152521
Email: 3085654926@QQ.COM
Country: China
ProdList: 1972
Advantage: 58

Guangzhou Reullei Pharmaceutical Technology Co., Ltd，

Tel: 13660253774
Email: joe.yang@reullei.com
Country: China
ProdList: 4994
Advantage: 58

Cato Research Chemicals Inc.

Tel: 13342851930
Email: 3008394369@qq.com
Country: China
ProdList: 15726
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Chemsigma International Co., Ltd.

Tel: +86-18136843612 +86-19951791336
Email: info@chemsigma.com
Country: China
ProdList: 1369
Advantage: 58

1571982-04-1, perampanel 3/4 hydrateRelated Search:

perampanel 3/4 hydrate

2-(1',6'-Dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)benzonitrile hydrate (4:3)

Perampanel hydrate (4:3)

Perampanel 3/4H2O

Perampanel Hydrate

4 hydrate

perampanel 3

3-(2-CYANOPHENYL)-1-PHENYL-5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 3/4 HYDRATE

1571982-04-1

4C23H15N3O3H2O