1627710-50-2

Product Name: 1627710-50-2
CAS No.: 1627710-50-2
Chemical Name: 1627710-50-2
Synonyms: LJH685;CS-2182;LJH685(LJH-685);LJH-685;LJH 685;LJH685;2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-;LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor
CBNumber: CB03060937
Molecular Formula: C22H21F2N3O
Formula Weight: 381.42
MOL File: 1627710-50-2.mol

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1627710-50-2 Property

Boiling point:: 481.1±45.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 5.86±0.25(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19913
Product name: LJH685
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19913
Product name: LJH685
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19913
Product name: LJH685
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 19913
Product name: LJH685
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: L468875
Product name: LJH685
Packaging: 10mg
Price: $625
Updated: 2021/12/16

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1627710-50-2 Chemical Properties,Usage,Production

Uses

LJH685 is a selective and potent RSK inhibitor (1). The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is linked to various cancers and its substrate phosphorylation is also related to the regulation of cell survival, proliferation, and cell polarity (2).

Biological Activity

ljh685 is a rsk (p90 ribosomal s6 kinase) inhibitor.the p90 ribosomal s6 kinase (rsk) family of serine/threonine kinases is found to be expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell proliferation, cell survival, as well as cell polarity.

in vitro

in a previous study, the structural analysis results confirmed the binding of ljh685 to the rsk2 n-terminal kinase atp-binding site, which suggested that the inhibitor ljh685 adopted an unusual nonplanar conformation that explained its excellent selectivity for rsk family kinases. in addition, ljh685 and it analog lji308 could efficiently inhibit rsk activity in vitro and in cells. moreover, in a subset of examined cell lines, the cellular inhibition of rsk and its phosphorylation of yb1 on ser102 were found to be closely associate with the inhibition of cell growth in an anchorage-independent growth setting [1].

IC 50

6 nm, 5 nm and 4 nm for the biochemical activities of rsk1, rsk2, and rsk3, respectively

References

[1] aronchik i, appleton ba,basham se,crawford k,del rosario m,doyle lv,estacio wf,lan j,lindvall mk,luu ca,ornelas e,venetsanakos e,shafer cm,jefferson ab. novel potent and selective inhibitors of p90 ribosomal s6 kinase reveal the heterogeneity of rsk function in mapk-driven cancers. mol cancer res.2014 may;12(5):803-12.

1627710-50-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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1627710-50-2 Suppliers

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1627710-50-2, 1627710-50-2Related Search:

LJH685

2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol

LJH685(LJH-685)

LJH-685;LJH 685;LJH685

CS-2182

Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-

LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor

1627710-50-2

C22H21F2N3O