Azido-PEG4-4-nitrophenyl carbonate

Product Name: Azido-PEG4-4-nitrophenyl carbonate
CAS No.: 1422540-98-4
Chemical Name: Azido-PEG4-4-nitrophenyl carbonate
Synonyms: N3-PEG4-NPC;N3-PEG4-4-NPC;Reaxys ID: 23366082;Azido-PEG4-4-nitrophenyl carbonate
CBNumber: CB03062355
Molecular Formula: C15H20N4O8
Formula Weight: 384.35
MOL File: 1422540-98-4.mol

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Azido-PEG4-4-nitrophenyl carbonate Property

storage temp.: Storage temp. 2-8°C
form: Viscous Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A965703
Product name: Azido-PEG4-4-nitrophenylcarbonate
Packaging: 50mg
Price: $265
Updated: 2021/12/16

BroadPharm

Product number: BP-22841
Product name: Azido-PEG4-4-nitrophenylcarbonate
Purity: 98%
Packaging: 1g
Price: $890
Updated: 2021/12/16

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Azido-PEG4-4-nitrophenyl carbonate Chemical Properties,Usage,Production

Description

Azido-PEG4-4-nitrophenyl carbonate is a PEG linker containing an azide group and an reactive nitrophenyl carbonate(NPC group). The NPC group is reactive towards the amino group of lysine by means of stable urethane linkages. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-4-nitrophenyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG4-4-nitrophenyl carbonate Preparation Products And Raw materials

Raw materials

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View Lastest Price from Azido-PEG4-4-nitrophenyl carbonate manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Azido-PEG4-4-nitrophenyl carbonate 1422540-98-4
Price: US $0.00/g
Min. Order: 1g
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-03-23

1422540-98-4, Azido-PEG4-4-nitrophenyl carbonateRelated Search:

Azido-PEG4-4-nitrophenyl carbonate

N3-PEG4-NPC

Reaxys ID: 23366082

N3-PEG4-4-NPC

1422540-98-4

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