AMG 9810

ChemicalBook > CAS DataBase List > AMG 9810

In vivo

Product Name: AMG 9810
CAS No.: 545395-94-6
Chemical Name: AMG 9810
Synonyms: 9810;CS-2548;AMG 9810;AMG 9810;AMG-9810;AMG 9810 >=98% (HPLC), powder;(2E)-N-(2，3-Dihydro-1，4-benzodi;3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE;3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide;(2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide;(2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE
CBNumber: CB0306302
Molecular Formula: C21H23NO3
Formula Weight: 337.41
MOL File: 545395-94-6.mol

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AMG 9810 Property

Boiling point:: 512.5±50.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >5mg/mL
pka: 12.22±0.20(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2731
Product name: AMG 9810
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $227
Updated: 2024/03/01

Sigma-Aldrich

Product number: A2731
Product name: AMG 9810
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $357.6
Updated: 2024/03/01

Alfa Aesar

Product number: J64202
Product name: AMG 9810
Packaging: 25mg
Price: $308
Updated: 2023/06/20

Cayman Chemical

Product number: 14715
Product name: AMG 9810
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 14715
Product name: AMG 9810
Purity: ≥98%
Packaging: 10mg
Price: $95
Updated: 2024/03/01

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AMG 9810 Chemical Properties,Usage,Production

In vivo

AMG9810 is effective at preventing capsaicin-induced eye wiping in a dose-dependent manner, and it reverses thermal and mechanical hyperalgesia in a model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant. At effective doses, AMG9810 does not show any significant effects on motor function. AMG9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain. AMG9810, promotes mouse skin tumor development. The topical application of AMG9810 results in a significant increase in the expression level of the epidermal growth factor receptor (EGFR) and its downstream Akt/mammalian target of rapamycin (mTOR)-signaling pathway.

Description

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC₅₀s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC₅₀s = 92.7 and 294 nM for human and rat, respectively), heat (IC₅₀s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC₅₀s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.

Uses

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.[Cayman Chemical]

Definition

ChEBI: 3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.

Biological Activity

AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC 50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

Biochem/physiol Actions

AMG 9810?is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.

storage

+4°C (desiccate)

References

[1]. gavva nr, tamir r, qu y, et al. amg 9810 [(e)-3-(4-t-butylphenyl)-n-(2, 3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (trpv1) antagonist with antihyperalgesic properties. j pharmacol exp ther, 2005, 313(1):474-84.

AMG 9810 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMG 9810 manufacturers

Career Henan Chemical Co

Product: (2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE 545395-94-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

545395-94-6, AMG 9810Related Search:

PSY-279 IBTU JYL-273 BCTC Acrylamide (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE AMG 9810 4-TERT-BUTYLSTYRENE 3-(4-TERT-BUTYL-PHENYL)-PROPENAL

3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE

AMG 9810

CS-2548

AMG 9810;AMG-9810

(2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE

3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide

9810

(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide

2-PropenaMide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-diMethylethyl)phenyl]-, (2E)-

AMG 9810 >=98% (HPLC), powder

(2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide

Transient receptor potential channels,inhibit,Inhibitor,AMG-9810,AMG9810,AMG 9810,TRP Channel

(2E)-N-(2，3-Dihydro-1，4-benzodi

545395-94-6

Vanilloid/TRPV channel