6-Chloro-3-methoxy-4-methylpyridazine
- Product Name
- 6-Chloro-3-methoxy-4-methylpyridazine
- CAS No.
- 89466-38-6
- Chemical Name
- 6-Chloro-3-methoxy-4-methylpyridazine
- Synonyms
- 6-Chloro-3-methoxy-4-methylpyridazine;Pyridazine, 6-chloro-3-methoxy-4-methyl-
- CBNumber
- CB03065644
- Molecular Formula
- C6H7ClN2O
- Formula Weight
- 158.59
- MOL File
- 89466-38-6.mol
6-Chloro-3-methoxy-4-methylpyridazine Property
- Melting point:
- 113 °C
- Boiling point:
- 293.8±35.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.29±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- X3927
- Product name
- 6-Chloro-3-Methoxy-4-methylpyridazine
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- X3927
- Product name
- 6-Chloro-3-Methoxy-4-methylpyridazine
- Packaging
- 5g
- Price
- $1011
- Updated
- 2021/12/16
- Product number
- CM126121
- Product name
- 6-chloro-3-methoxy-4-methylpyridazine
- Purity
- 98%
- Packaging
- 10g
- Price
- $1108
- Updated
- 2021/12/16
- Product number
- CD11026344
- Product name
- 6-Chloro-3-methoxy-4-methylpyridazine
- Purity
- 98%
- Packaging
- 10g
- Price
- $1174
- Updated
- 2021/12/16
- Product number
- 89466386
- Product name
- 6-Chloro-3-methoxy-4-methylpyridazine
- Packaging
- 10g
- Price
- $1256.1
- Updated
- 2021/12/16
6-Chloro-3-methoxy-4-methylpyridazine Chemical Properties,Usage,Production
Synthesis
1722-10-7
74-88-4
89466-38-6
The general procedure for the synthesis of 3-methoxy-4-methyl-6-chloropyridazine from 6-methoxy-3-chloropyridazine and iodomethane was as follows: 2,2,6,6-tetramethylpiperidine (12.9 mL, 76.1 mmol) was dissolved in tetrahydrofuran (100 mL) under the protection of nitrogen and cooled down to -78°C. A hexane solution of 2.5 M n-butyllithium (30.4 mL, 76.1 mmol) was slowly added, followed by warming the reaction mixture to 0 °C and stirring for 1 hour. After cooling again to -78 °C, a tetrahydrofuran solution (75 mL, 34.6 mmol) of 0.46 M 3-chloro-6-methoxypyridazine was slowly added. After continued stirring at -78 °C for 1 h, iodomethane (4.74 mL, 76.1 mmol) was added and stirring was continued at the same temperature for 30 min. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (50 mL), warmed to room temperature, diluted with water (50 mL) and extracted with ethyl acetate (2 x 250 mL). The organic phases were combined, washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 3-methoxy-4-methyl-6-chloropyridazine (3.31 g, 60% yield). Mass spectrum (APCI) m/z = 159.0 (M + H).
References
[1] Patent: WO2017/70708, 2017, A1. Location in patent: Paragraph 00551
6-Chloro-3-methoxy-4-methylpyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-3-methoxy-4-methylpyridazine manufacturers
- Product
- 6-Chloro-3-methoxy-4-methylpyridazine 89466-38-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 20kgs/month
- Release date
- 2021-11-10