Methyl 2-amino-4-hydroxybenzoate
Uses- Product Name
- Methyl 2-amino-4-hydroxybenzoate
- CAS No.
- 401568-70-5
- Chemical Name
- Methyl 2-amino-4-hydroxybenzoate
- Synonyms
- Prucalopride Impurity44;METHYL 2-AMINO-4-HYDROXYBENZOAT;Methyl 2-amino-4-hydroxybenzoate;Prucalopride Succinate iMpurit 44;Benzoic acid, 2-amino-4-hydroxy-, methyl ester;Methyl 2-amino-4-hydroxybenzoate ISO 9001：2015 REACH
- CBNumber
- CB03066333
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 401568-70-5.mol
Methyl 2-amino-4-hydroxybenzoate Property
- Melting point:
- 154-155 °C
- Boiling point:
- 330.6±22.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 8.41±0.18(Predicted)
- Appearance
- Light yellow to light brown Solid
- CAS DataBase Reference
- 401568-70-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M288463
- Product name
- methyl2-amino-4-hydroxybenzoate
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 3520AL
- Product name
- Methyl2-amino-4-hydroxybenzoate
- Packaging
- 100mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- CHM0379502
- Product name
- METHYL-2-AMINO-4-HYDROXYBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.35
- Updated
- 2021/12/16
- Product number
- A148171
- Product name
- Methyl2-amino-4-hydroxybenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $516
- Updated
- 2021/12/16
- Product number
- CM154800
- Product name
- methyl2-amino-4-hydroxybenzoate
- Purity
- 95%
- Packaging
- 5g
- Price
- $572
- Updated
- 2021/12/16
Methyl 2-amino-4-hydroxybenzoate Chemical Properties,Usage,Production
Uses
This product is used as an organic and pharmaceutical intermediate.
Synthesis
178758-50-4
401568-70-5
Step 3: Methyl 4-hydroxy-2-nitrobenzoate (4.410 g, 22.369 mmol) was dissolved in methanol (80 mL) under the protection of nitrogen atmosphere and stirred at room temperature. Ammonium formate (5.642 g, 89.475 mmol) and 5% Pd/C catalyst (450 mg) were subsequently added. After the reaction lasted for 5 h, the reaction mixture was filtered through a diatomaceous earth pad and washed well with methanol. The filtrate was concentrated under reduced pressure and the resulting residue was subjected to liquid-liquid partitioning with ethyl acetate (150 mL) and water (40 mL). After vigorous shaking, the organic layer was separated and washed sequentially with water (3 × 30 mL) and saturated saline (2 × 30 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-amino-4-hydroxybenzoate (3.593 g, 21.494 mmol, 96% yield) as an off-white solid with a melting point of 113-118 °C. The product was separated by 1H NMR (1H NMR, 1H NMR, 1H NMR, 1H NMR). The product was characterized by 1H NMR (DMSO-d6): δ 3.70 (s, 3H), 5.98 (dd, 1H), 6.10 (s, 1H), 6.59 (s, 1H), 7.54 (d, 1H), 9.81 (s, 1H); the mass spectrum [ES(-)] showed m/z 166 ([M-H]-).
References
[1] Patent: US2005/70584, 2005, A1. Location in patent: Page/Page column 24
[2] Journal of the Chemical Society, 1949, p. 1498,1502
Methyl 2-amino-4-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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