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STING agonist-1

Product Name
STING agonist-1
CAS No.
702662-50-8
Chemical Name
STING agonist-1
Synonyms
STING agonist-1;STING agonist-1 (G10);STING agonist-1, 10 mM in DMSO;G10, STING signaling activator;4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-;inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
CBNumber
CB03067022
Molecular Formula
C21H16ClFN2O3S
Formula Weight
430.88
MOL File
702662-50-8.mol
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STING agonist-1 Property

Boiling point:
668.3±55.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.5 mg/ml
form 
A crystalline solid
pka
13.53±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22353
Product name
G10
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
22353
Product name
G10
Purity
≥98%
Packaging
5mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
22353
Product name
G10
Purity
≥98%
Packaging
10mg
Price
$164
Updated
2024/03/01
Cayman Chemical
Product number
22353
Product name
G10
Purity
≥98%
Packaging
25mg
Price
$438
Updated
2021/12/16
TRC
Product number
G932043
Product name
G10
Packaging
2.5mg
Price
$165
Updated
2021/12/16
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STING agonist-1 Chemical Properties,Usage,Production

Description

G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

Uses

G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV).

storage

Store at -20°C

STING agonist-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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702662-50-8, STING agonist-1Related Search:


  • STING agonist-1 (G10)
  • 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
  • STING agonist-1
  • 2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-
  • 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide
  • inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
  • G10, STING signaling activator
  • STING agonist-1, 10 mM in DMSO
  • 702662-50-8
  • API