C-DIM12

Product Name: C-DIM12
CAS No.: 178946-89-9
Chemical Name: C-DIM12
Synonyms: CS-2311;C-DIMI2;C-DIM12;C-DIM12, >98%;C-DIM12 (C-DIM-12;C-DIM12, 178946-89-9;C-DIM12 >=98% (HPLC);C-DIM12, 10 mM in DMSO;bis(3-indolyl)-4-chlorophenylmethane;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
CBNumber: CB03067198
Molecular Formula: C23H17ClN2
Formula Weight: 356.85
MOL File: 178946-89-9.mol

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C-DIM12 Property

Melting point:: 76-77 °C
Boiling point:: 585.6±45.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
form: solid
pka: 16.40±0.30(Predicted)
color: Orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI: 1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
InChIKey: LTLRXTDMXOFBDW-UHFFFAOYSA-N
SMILES: ClC(C=C1)=CC=C1C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1508
Product name: C-DIM12
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $77.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1508
Product name: C-DIM12
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $312.9
Updated: 2025/07/31

TCI Chemical

Product number: C3467
Product name: C-DIM 12
Packaging: 50MG
Price: $345
Updated: 2025/07/31

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 10mg
Price: $94
Updated: 2024/03/01

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C-DIM12 Chemical Properties,Usage,Production

Description

C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.

Uses

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

in vivo

C-DIM12 (25 mg/kg for i.p., 14 day) modulates glial reactivity in MPTP-Induced Parkinsonism mice^[2].
C-DIM12 (50-100 mg/kg for i.p., three times ) attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice^[3].
C-DIM12 (30 mg/kg for i.p., 30 day) inhibits tumor growth and autophagy, and induces apoptosis in NURR1-KO cells orthotopic xenograft^[1].
Pharmacokinetic Analysis in C57BL/6 male mice^[1]

Route	Organ	Dose (mg/kg)	Area under Curve (ng/mL*min)	t_1/2 (min)	C_max (ng/mL)
i.g.	Plasma	25	539,220	249	1120
i.g.	Brain	25	2,273,711	265	3622

Animal Model:	MPTP-induced C57BL/6 male Parkinsonism mice ^[2]
Dosage:	25 mg/kg/day, 14day
Administration:	Intragastric gavage (i.g.)
Result:	Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.

Animal Model:	The ICR mice model of intracerebral hemorrhage induced by collagenase type VII^[3]
Dosage:	50 and 100mg/kg/day at a 24-h interval, three times
Administration:	Orally administration
Result:	Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2. Preserved axonal structures in the internal capsule and axonal transport function. Decreased of iNOS mRNA expression.

Animal Model:	MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models^[1]
Dosage:	30 mg/kg, 30 day
Administration:	Intraperitoneal injection (i.p.)
Result:	Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.

IC 50

Nurr1/NR4A2

storage

Store at -20°C

References

[1] TERUO INAMOTO. 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.[J]. Molecular Cancer Therapeutics, 2008: 3825-3833. DOI:10.1158/1535-7163.mct-08-0730
[2] XI LI Stephen S Syng Ook Lee. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells[J]. Biochemical pharmacology, 2012, 83 10: Pages 1445-1455. DOI:10.1016/j.bcp.2012.02.021
[3] BRIANA R DE MIRANDA. The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.[J]. Molecular Pharmacology, 2015, 87 6: 1021-1034. DOI:10.1124/mol.114.095398
[4] Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease

C-DIM12 Preparation Products And Raw materials

Raw materials

Preparation Products

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C-DIM12 Suppliers

China 88 India 1 United Kingdom 1 United States 14 Global 104

Shanghai Boyle Chemical Co., Ltd.

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MedChemexpress LLC

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Shanghai Lollane Biological Technology Co.,Ltd.

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View Lastest Price from C-DIM12 manufacturers

Career Henan Chemical Co

Product: C-DIM12 178946-89-9
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

178946-89-9, C-DIM12Related Search:

ZM 447439 TYRPHOSTIN AG 879 17-AAG SU 4312

C-DIM12

C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane)

C-DIMI2

3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole

C-DIM12, 178946-89-9

C-DIM12 (C-DIM-12

CS-2311

C-DIM12, >98%

bis(3-indolyl)-4-chlorophenylmethane

1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-

C-DIM12 >=98% (HPLC)

inhibit,Inhibitor,C-DIM-12,CDIM12,C-DIM12,C DIM12,Apoptosis

3,3'-((4-Chlorophenyl)methylene)bis(1H-indole)

C-DIM12, 10 mM in DMSO

178946-89-9