C-DIM12
- Product Name
- C-DIM12
- CAS No.
- 178946-89-9
- Chemical Name
- C-DIM12
- Synonyms
- CS-2311;C-DIMI2;C-DIM12;C-DIM12, >98%;C-DIM12 (C-DIM-12;C-DIM12, 178946-89-9;C-DIM12 >=98% (HPLC);C-DIM12, 10 mM in DMSO;bis(3-indolyl)-4-chlorophenylmethane;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
- CBNumber
- CB03067198
- Molecular Formula
- C23H17ClN2
- Formula Weight
- 356.85
- MOL File
- 178946-89-9.mol
C-DIM12 Property
- Melting point:
- 76-77 °C
- Boiling point:
- 585.6±45.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
- form
- solid
- pka
- 16.40±0.30(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1508
- Product name
- C-DIM12
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $77.7
- Updated
- 2025/07/31
- Product number
- SML1508
- Product name
- C-DIM12
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $312.9
- Updated
- 2025/07/31
- Product number
- C3467
- Product name
- C-DIM 12
- Packaging
- 50MG
- Price
- $345
- Updated
- 2025/07/31
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $94
- Updated
- 2024/03/01
C-DIM12 Chemical Properties,Usage,Production
Description
C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.
Uses
C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].
in vivo
C-DIM12 (25 mg/kg for i.p., 14 day) modulates glial reactivity in MPTP-Induced Parkinsonism mice[2].
C-DIM12 (50-100 mg/kg for i.p., three times ) attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice[3].
C-DIM12 (30 mg/kg for i.p., 30 day) inhibits tumor growth and autophagy, and induces apoptosis in NURR1-KO cells orthotopic xenograft[1].
Pharmacokinetic Analysis in C57BL/6 male mice[1]
| Route | Organ | Dose (mg/kg) | Area under Curve (ng/mL*min) | t1/2 (min) | Cmax (ng/mL) |
| i.g. | Plasma | 25 | 539,220 | 249 | 1120 |
| i.g. | Brain | 25 | 2,273,711 | 265 | 3622 |
| Animal Model: | MPTP-induced C57BL/6 male Parkinsonism mice [2] |
| Dosage: | 25 mg/kg/day, 14day |
| Administration: | Intragastric gavage (i.g.) |
| Result: | Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes. |
| Animal Model: | The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3] |
| Dosage: | 50 and 100mg/kg/day at a 24-h interval, three times |
| Administration: | Orally administration |
| Result: | Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2. Preserved axonal structures in the internal capsule and axonal transport function. Decreased of iNOS mRNA expression. |
| Animal Model: | MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1] |
| Dosage: | 30 mg/kg, 30 day |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis. |
IC 50
Nurr1/NR4A2
storage
Store at -20°C
References
[1] TERUO INAMOTO. 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.[J]. Molecular Cancer Therapeutics, 2008: 3825-3833. DOI:10.1158/1535-7163.mct-08-0730
[2] XI LI Stephen S Syng Ook Lee. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells[J]. Biochemical pharmacology, 2012, 83 10: Pages 1445-1455. DOI:10.1016/j.bcp.2012.02.021
[3] BRIANA R DE MIRANDA. The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.[J]. Molecular Pharmacology, 2015, 87 6: 1021-1034. DOI:10.1124/mol.114.095398
[4] Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease
C-DIM12 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from C-DIM12 manufacturers
- Product
- C-DIM12 178946-89-9
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20