C-DIM12
- Product Name
- C-DIM12
- CAS No.
- 178946-89-9
- Chemical Name
- C-DIM12
- Synonyms
- CS-2311;C-DIMI2;C-DIM12;C-DIM12, >98%;C-DIM12 (C-DIM-12;C-DIM12, 178946-89-9;C-DIM12 >=98% (HPLC);C-DIM12, 10 mM in DMSO;bis(3-indolyl)-4-chlorophenylmethane;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
- CBNumber
- CB03067198
- Molecular Formula
- C23H17ClN2
- Formula Weight
- 356.85
- MOL File
- 178946-89-9.mol
C-DIM12 Property
- Melting point:
- 76-77 °C
- Boiling point:
- 585.6±45.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
- form
- solid
- pka
- 16.40±0.30(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $209
- Updated
- 2024/03/01
- Product number
- 22951
- Product name
- C-DIM12
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $583
- Updated
- 2024/03/01
- Product number
- 5821
- Product name
- C-DIM12
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $138
- Updated
- 2021/12/16
C-DIM12 Chemical Properties,Usage,Production
Description
C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.
storage
Store at -20°C
References
1) Inamoto et al. (2008), 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth; Mol Cancer Ther., 7 3825 2) Li et al. (2012), Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3’-indoyl)-1-(aromatic)methane analogs in pancreatic cancer cells; Biochem. Pharmacol., 83 1445 3) De Miranda et al. (2015), The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-chlorophenyl)Methane blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor kB; Mol. Pharmacol., 87 1021 4) De Miranda et al. (2013), Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease; J. Pharmacol. Exp. Ther., 345 125
C-DIM12 Preparation Products And Raw materials
Raw materials
Preparation Products
C-DIM12 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5793
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 13621943973
- Fax
- -
- sales@shjiyipharmatech.com
- Country
- China
- ProdList
- 1166
- Advantage
- 55
- Tel
- 400-026-9899
- Fax
- +86-731-86905278
- Country
- China
- ProdList
- 71
- Advantage
- 50
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4571
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
View Lastest Price from C-DIM12 manufacturers
- Product
- C-DIM12 178946-89-9
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20