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C-DIM12

Product Name
C-DIM12
CAS No.
178946-89-9
Chemical Name
C-DIM12
Synonyms
CS-2311;C-DIMI2;C-DIM12;C-DIM12, >98%;C-DIM12 (C-DIM-12;C-DIM12, 178946-89-9;C-DIM12 >=98% (HPLC);C-DIM12, 10 mM in DMSO;bis(3-indolyl)-4-chlorophenylmethane;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
CBNumber
CB03067198
Molecular Formula
C23H17ClN2
Formula Weight
356.85
MOL File
178946-89-9.mol
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C-DIM12 Property

Melting point:
76-77 °C
Boiling point:
585.6±45.0 °C(Predicted)
Density 
1.324±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
form 
solid
pka
16.40±0.30(Predicted)
color 
Orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1508
Product name
C-DIM12
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$77.7
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1508
Product name
C-DIM12
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$312.9
Updated
2025/07/31
TCI Chemical
Product number
C3467
Product name
C-DIM 12
Packaging
50MG
Price
$345
Updated
2025/07/31
Cayman Chemical
Product number
22951
Product name
C-DIM12
Purity
≥98%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
22951
Product name
C-DIM12
Purity
≥98%
Packaging
10mg
Price
$94
Updated
2024/03/01
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C-DIM12 Chemical Properties,Usage,Production

Description

C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.

Uses

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

in vivo

C-DIM12 (25 mg/kg for i.p., 14 day) modulates glial reactivity in MPTP-Induced Parkinsonism mice[2].
C-DIM12 (50-100 mg/kg for i.p., three times ) attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice[3].
C-DIM12 (30 mg/kg for i.p., 30 day) inhibits tumor growth and autophagy, and induces apoptosis in NURR1-KO cells orthotopic xenograft[1].
Pharmacokinetic Analysis in C57BL/6 male mice[1]

RouteOrganDose (mg/kg)Area under Curve (ng/mL*min)t1/2 (min)Cmax (ng/mL)
i.g.Plasma25539,2202491120
i.g.Brain252,273,7112653622
Animal Model:MPTP-induced C57BL/6 male Parkinsonism mice [2]
Dosage:25 mg/kg/day, 14day
Administration:Intragastric gavage (i.g.)
Result:Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.
Animal Model:The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3]
Dosage:50 and 100mg/kg/day at a 24-h interval, three times
Administration:Orally administration
Result:Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2.
Preserved axonal structures in the internal capsule and axonal transport function.
Decreased of iNOS mRNA expression.
Animal Model:MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1]
Dosage:30 mg/kg, 30 day
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.

IC 50

Nurr1/NR4A2

storage

Store at -20°C

References

[1] TERUO INAMOTO. 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.[J]. Molecular Cancer Therapeutics, 2008: 3825-3833. DOI:10.1158/1535-7163.mct-08-0730
[2] XI LI  Stephen S  Syng Ook Lee. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells[J]. Biochemical pharmacology, 2012, 83 10: Pages 1445-1455. DOI:10.1016/j.bcp.2012.02.021
[3] BRIANA R DE MIRANDA. The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.[J]. Molecular Pharmacology, 2015, 87 6: 1021-1034. DOI:10.1124/mol.114.095398
[4] Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease

C-DIM12 Preparation Products And Raw materials

Raw materials

Preparation Products

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C-DIM12 Suppliers

China 88 India 1 United Kingdom 1 United States 14 Global 104
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View Lastest Price from C-DIM12 manufacturers

Career Henan Chemical Co
Product
C-DIM12 178946-89-9
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

178946-89-9, C-DIM12Related Search:

ZM 447439 TYRPHOSTIN AG 879 17-AAG SU 4312

  • C-DIM12
  • C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane)
  • C-DIMI2
  • 3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
  • C-DIM12, 178946-89-9
  • C-DIM12 (C-DIM-12
  • CS-2311
  • C-DIM12, >98%
  • bis(3-indolyl)-4-chlorophenylmethane
  • 1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-
  • C-DIM12 >=98% (HPLC)
  • inhibit,Inhibitor,C-DIM-12,CDIM12,C-DIM12,C DIM12,Apoptosis
  • 3,3'-((4-Chlorophenyl)methylene)bis(1H-indole)
  • C-DIM12, 10 mM in DMSO
  • 178946-89-9