C-DIM12

Product Name: C-DIM12
CAS No.: 178946-89-9
Chemical Name: C-DIM12
Synonyms: CS-2311;C-DIMI2;C-DIM12;C-DIM12, >98%;C-DIM12 (C-DIM-12;C-DIM12, 178946-89-9;C-DIM12 >=98% (HPLC);C-DIM12, 10 mM in DMSO;bis(3-indolyl)-4-chlorophenylmethane;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
CBNumber: CB03067198
Molecular Formula: C23H17ClN2
Formula Weight: 356.85
MOL File: 178946-89-9.mol

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C-DIM12 Property

Melting point:: 76-77 °C
Boiling point:: 585.6±45.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
form: solid
pka: 16.40±0.30(Predicted)
color: Orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 10mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 25mg
Price: $209
Updated: 2024/03/01

Cayman Chemical

Product number: 22951
Product name: C-DIM12
Purity: ≥98%
Packaging: 100mg
Price: $583
Updated: 2024/03/01

Tocris

Product number: 5821
Product name: C-DIM12
Purity: ≥98%(HPLC)
Packaging: 10
Price: $138
Updated: 2021/12/16

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C-DIM12 Chemical Properties,Usage,Production

Description

C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.

storage

Store at -20°C

References

1) Inamoto et al. (2008), 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth; Mol Cancer Ther., 7 3825 2) Li et al. (2012), Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3’-indoyl)-1-(aromatic)methane analogs in pancreatic cancer cells; Biochem. Pharmacol., 83 1445 3) De Miranda et al. (2015), The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-chlorophenyl)Methane blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor kB; Mol. Pharmacol., 87 1021 4) De Miranda et al. (2013), Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease; J. Pharmacol. Exp. Ther., 345 125

C-DIM12 Preparation Products And Raw materials

Raw materials

Preparation Products

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C-DIM12 Suppliers

China 73 India 1 United Kingdom 1 United States 13 Global 88

MedChemexpress LLC

Tel: 021-58955995
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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

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TargetMol Chemicals Inc.

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Focus Biomolecules

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Cayman Chemical Company

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United States Biological

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Combi-Blocks Inc.

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View Lastest Price from C-DIM12 manufacturers

Career Henan Chemical Co

Product: C-DIM12 178946-89-9
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

178946-89-9, C-DIM12Related Search:

ZM 447439 TYRPHOSTIN AG 879 17-AAG SU 4312

C-DIM12

C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane)

C-DIMI2

3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole

C-DIM12, 178946-89-9

C-DIM12 (C-DIM-12

CS-2311

C-DIM12, >98%

bis(3-indolyl)-4-chlorophenylmethane

1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-

C-DIM12 >=98% (HPLC)

inhibit,Inhibitor,C-DIM-12,CDIM12,C-DIM12,C DIM12,Apoptosis

3,3'-((4-Chlorophenyl)methylene)bis(1H-indole)

1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-

C-DIM12, 10 mM in DMSO

178946-89-9