7-bromoimidazo[1,5-a]pyridine

Product Name: 7-bromoimidazo[1,5-a]pyridine
CAS No.: 865156-48-5
Chemical Name: 7-bromoimidazo[1,5-a]pyridine
Synonyms: 7-bromoimidazo[1,5-a]pyridine;Imidazo[1,5-a]pyridine, 7-bromo-
CBNumber: CB03067259
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: 865156-48-5.mol

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7-bromoimidazo[1,5-a]pyridine Property

Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 6.02±0.30(Predicted)
Appearance: Yellow to brown Solid
CAS DataBase Reference: 865156-48-5

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 1726DT
Product name: 7-Bromoimidazo[1,5-a]pyridine
Packaging: 1g
Price: $698
Updated: 2021/12/16

Alichem

Product number: 865156485
Product name: 7-Bromoimidazo[1,5-a]pyridine
Packaging: 5g
Price: $1894.76
Updated: 2021/12/16

AccelPharmtech

Product number: A3466
Product name: 7-bromo-Imidazo[1,5-a]pyridine
Purity: 97.00%
Packaging: 1G
Price: $2640
Updated: 2021/12/16

AccelPharmtech

Product number: A3466
Product name: 7-bromo-Imidazo[1,5-a]pyridine
Purity: 97.00%
Packaging: 5G
Price: $4530
Updated: 2021/12/16

AccelPharmtech

Product number: A3466
Product name: 7-bromo-Imidazo[1,5-a]pyridine
Purity: 97.00%
Packaging: 25G
Price: $8510
Updated: 2021/12/16

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7-bromoimidazo[1,5-a]pyridine Chemical Properties,Usage,Production

Uses

7-Bromoimidazo[1,5-a]pyridine is used in the discovery of novel imidazopyridine GSK-3β inhibitors supported by computational approaches.

Synthesis

865156-49-6

865156-48-5

General procedure for the synthesis of 7-bromoimidazo[1,5-a]pyridine from N-((4-bromopyridin-2-yl)methyl)formamide: To a 100 mL round bottom flask was added a solution of N-((4-bromopyridin-2-yl)methyl)formamide (Compound 39.2, 3.0 g, 90%, 12.6 mmol) in dichloromethane (20 mL). The solution was cooled to 0-5 °C and then trifluoroacetic anhydride (1.93 mL, 13.9 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 1 h. Subsequently, the pH was adjusted to 7 by slow addition of saturated aqueous sodium carbonate solution. The aqueous phase was extracted with dichloromethane (3 x 20 mL), the organic layers were combined and washed with brine (3 x 20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1/1) as eluent to afford 7-bromoimidazo[1,5-a]pyridine as a brown solid.

References

[1] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 106; 107
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 121; 122
[3] Patent: WO2005/90305, 2005, A1. Location in patent: Page/Page column 29-30
[4] Patent: WO2005/90304, 2005, A1. Location in patent: Page/Page column 38

7-bromoimidazo[1,5-a]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-bromoimidazo[1,5-a]pyridine Suppliers

China 42 United States 2 Global 44

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