ChemicalBook > CAS DataBase List > N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- Product Name
- N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- CAS No.
- 383418-30-2
- Chemical Name
- N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- Synonyms
- HPA-12;N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide;Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- CBNumber
- CB03069617
- Molecular Formula
- C22H37NO3
- Formula Weight
- 363.53
- MOL File
- 383418-30-2.mol
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N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Property
- storage temp.
- 2-8°C
- solubility
- Chloroform: soluble; DMSO: soluble
- form
- powder to crystal
- color
- White to Almost white
- CAS DataBase Reference
- 383418-30-2
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Safety
- HS Code
- 2924.29.7790
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2894
- Product name
- HPA-12
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $212.41
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML2894
- Product name
- HPA-12
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $982
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1553
- Product name
- N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- Purity
- >98.0%(HPLC)
- Packaging
- 5mg
- Price
- $529
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 28350
- Product name
- HPA-12
- Packaging
- 5mg
- Price
- $243
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28350
- Product name
- HPA-12
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1154
- Updated
- 2024/03/01
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N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Chemical Properties,Usage,Production
Description
HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM.
Uses
HPA-12 is an intracellular ceramide transport protein inhibitor[1].
References
[1] Berke? D, et al. Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors. Chemistry. 2016 Dec 5;22(49):17514-17525. DOI:10.1002/chem.201602947
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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