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DESMOSTEROL

Product Name
DESMOSTEROL
CAS No.
313-04-2
Chemical Name
DESMOSTEROL
Synonyms
Desmostero;esmosterol;DESMOSTEROL;24-DEHYDROCHOLESTEROL;Cholesterol impurity B;desmosterol crystalline;Cholesta-5,24-dien-3-ol;5,24-Cholestadien-3β-ol;Cholesterol Impurity 12;5, 24-CHOLESTADIEN-3β-OL
CBNumber
CB0307682
Molecular Formula
C27H44O
Formula Weight
384.65
MOL File
313-04-2.mol
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DESMOSTEROL Property

Melting point:
121.5°, also reported as 119-119.5°
alpha 
D27 -41.0° (c = 1 in chloroform)
Boiling point:
483.2±14.0 °C(Predicted)
Density 
1.00±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
15.03±0.70(Predicted)
color 
Wihte to Off-White
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D6513
Product name
Desmosterol
Purity
≥84% (GC)
Packaging
5mg
Price
$86
Updated
2024/03/01
Sigma-Aldrich
Product number
D6513
Product name
Desmosterol
Purity
≥84% (GC)
Packaging
10mg
Price
$149
Updated
2024/03/01
Cayman Chemical
Product number
14943
Product name
24-dehydro Cholesterol
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
14943
Product name
24-dehydro Cholesterol
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
14943
Product name
24-dehydro Cholesterol
Purity
≥98%
Packaging
10mg
Price
$120
Updated
2024/03/01
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DESMOSTEROL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical]

Uses

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

Uses

A metabolite of Cholesterol (C432501).

Definition

ChEBI: A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.

General Description

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

Biochem/physiol Actions

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

DESMOSTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

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DESMOSTEROL Suppliers

MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Tianchang city Chunfeng Fine Synthetic Material Plant
Tel
0550-7039583 0550-7552998 13905508100
Fax
+86 (550) 702-4815
Email
ycgquan@163.com
Country
China
ProdList
16
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
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View Lastest Price from DESMOSTEROL manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Desmosterol 313-04-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19

313-04-2, DESMOSTEROLRelated Search:


  • 3BETA-HYDROXY-5,24-CHOLESTADIENE
  • 5,24-CHOLESTADIEN-3BETA-OL
  • 24-DEHYDROCHOLESTEROL
  • DESMOSTEROL
  • Desmostero
  • Cholesta-5,24-dien-3beta-ol
  • Cholesta-5,24-dien-3-ol
  • Cholesta-5,24-dien-3-ol, (3beta)-
  • desmosterol crystalline
  • (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • 24-Dehydrocholesterol, 3β-Hydroxy-5,24-cholestadiene, 5,24-Cholestadien-3β-ol
  • 24,25-Didehydrocholesterol
  • (3S,8S,9S,10R,13R,14S,17R)-10,13-diMethyl-17-((R)-6-Methylhept-5-en-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • 3-hydroxy-5,24-cholestadiene
  • 5,24-Cholestadien-3β-ol
  • 3-HYDROXY-5,24-CHOLESTADIENE;DESMOSTEROL
  • Cholesterol Impurity 12
  • Cholesterol impurity B
  • Cholesterol EP Impurity B (Desmosterol)
  • Cholesta-5,24-dien-3-ol, (3β)-
  • (3β)-Cholesta-5,24-dien-3-ol
  • Cholesta-5,24-dien-3-ol,(3b)-
  • c h ole sta -5,24-d i e n-3β-ol (d e smoste rol)
  • esmosterol
  • 5, 24-CHOLESTADIEN-3β-OL
  • 3β-hydroxy-5,24-cholestadiene
  • Desmosterol 24-Dehydrocholesterol
  • 313-04-2
  • BioChemical
  • Metabolomics
  • Lipid Library
  • Metabolic Libraries
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids