DESMOSTEROL
- Product Name
- DESMOSTEROL
- CAS No.
- 313-04-2
- Chemical Name
- DESMOSTEROL
- Synonyms
- Desmostero;esmosterol;DESMOSTEROL;24-DEHYDROCHOLESTEROL;Cholesterol impurity B;desmosterol crystalline;Cholesta-5,24-dien-3-ol;5,24-Cholestadien-3β-ol;Cholesterol Impurity 12;5, 24-CHOLESTADIEN-3β-OL
- CBNumber
- CB0307682
- Molecular Formula
- C27H44O
- Formula Weight
- 384.65
- MOL File
- 313-04-2.mol
DESMOSTEROL Property
- Melting point:
- 121.5°, also reported as 119-119.5°
- alpha
- D27 -41.0° (c = 1 in chloroform)
- Boiling point:
- 483.2±14.0 °C(Predicted)
- Density
- 1.00±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.03±0.70(Predicted)
- color
- Wihte to Off-White
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D6513
- Product name
- Desmosterol
- Purity
- ≥84% (GC)
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- D6513
- Product name
- Desmosterol
- Purity
- ≥84% (GC)
- Packaging
- 10mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
DESMOSTEROL Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical]
Uses
Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.
Uses
A metabolite of Cholesterol (C432501).
Definition
ChEBI: A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
General Description
Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.
Biochem/physiol Actions
Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.
DESMOSTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DESMOSTEROL manufacturers
- Product
- Desmosterol 313-04-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19