Side chain for meropenem
- Product Name
- Side chain for meropenem
- CAS No.
- 96034-64-9
- Chemical Name
- Side chain for meropenem
- Synonyms
- Side Chain of MeropeneM;Side chain for Meropenem(2S-CIS);4-Nitrobenzyl (2S,4S)-2-(Dimethylcarbamoyl)-4-mercapto-1-pyrrolidinecarboxylate;2S-CIS PNB;Meropenem Powder;2S-CIS(SIDE CHAIN);MEROPENEM SIDE CHAIN;Meropenem Impurity 2;Side chain for Merop;Meropenem Sodium Salt
- CBNumber
- CB0308205
- Molecular Formula
- C15H19N3O5S
- Formula Weight
- 353.39
- MOL File
- 96034-64-9.mol
Side chain for meropenem Property
- Melting point:
- 117.0 to 121.0 °C
- Boiling point:
- 555.8±50.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- Flash point:
- 289.9 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 9.94±0.40(Predicted)
- color
- Pale Yellow to Light Yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C15H19N3O5S/c1-16(2)14(19)13-7-12(24)8-17(13)15(20)23-9-10-3-5-11(6-4-10)18(21)22/h3-6,12-13,24H,7-9H2,1-2H3/t12-,13-/m0/s1
- InChIKey
- VGLBNJWGUYQZHD-STQMWFEESA-N
- SMILES
- N1(C(OCC2=CC=C([N+]([O-])=O)C=C2)=O)C[C@@H](S)C[C@H]1C(N(C)C)=O
- CAS DataBase Reference
- 96034-64-9(CAS DataBase Reference)
Safety
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N0828
- Product name
- 4-Nitrobenzyl (2S,4S)-2-(Dimethylcarbamoyl)-4-mercapto-1-pyrrolidinecarboxylate
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $158
- Updated
- 2025/07/31
- Product number
- N0828
- Product name
- 4-Nitrobenzyl (2S,4S)-2-(Dimethylcarbamoyl)-4-mercapto-1-pyrrolidinecarboxylate
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $548
- Updated
- 2025/07/31
- Product number
- D456550
- Product name
- (2S,4S)-2-(Dimethylaminocarbonyl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)-1-pyrrolidine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD151235
- Product name
- (2S,4S)-2-(Dimethylaminocarbonyl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)-1-pyrrolidine
- Packaging
- 25mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FD151235
- Product name
- (2S,4S)-2-(Dimethylaminocarbonyl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)-1-pyrrolidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
Side chain for meropenem Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
Carbapenem antibiotic. Antibacterial
Uses
An intermediate used for the synthesis of Meropenem.
Uses
Side chain for meropenem
Synthesis
127966-47-6
506-59-2
96034-64-9
600 mL of N,N-dimethylformamide (DMF) was added to the reaction flask and the temperature of the reaction system was lowered to 0°C to 5°C. Subsequently, 179.5 g (0.55 mol) of (2S,4S)-1-carboxy-4-mercaptopyrrolidine (Formula VI) was added. Next, 66.8 g (0.66 mol) of diisopropylethylamine was added and the reaction mixture was stirred for 10 minutes. Then, 89.7 g (1.10 mol) of dimethylamine hydrochloride was added, and the reaction temperature was maintained between 0 °C and 5 °C, and the reaction continued to be stirred for 3 hours. Upon completion of the reaction, 500 mL of ice water was quickly added to the reaction mixture and stirred to precipitate a large amount of solid. The solid product was collected by filtration and the filter cake was washed with 200 mL of water. Finally, the product was dried under reduced pressure at 65 °C for 15 h to afford 179.4 g (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-(N,N-dimethylcarbamoyl)-4-mercapto-pyrrolidine (Formula VII) in 92.3% molar yield and 99.3% HPLC purity. The mass spectral data of compound VII were as follows: molecular formula C15H19N3O5S, molecular weight 353.4, [M+H]+: 354.6.
References
[1] Patent: CN105439932, 2016, A. Location in patent: Paragraph 0075; 0076; 0077
[2] Patent: CN105439933, 2016, A. Location in patent: Paragraph 0062; 0063; 0064
Side chain for meropenem Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Side chain for meropenem manufacturers
- Product
- Side chain of Meropenem 96034-64-9
- Price
- US $1000.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 70 tons
- Release date
- 2025-08-04
- Product
- Side chain for meropenem 96034-64-9
- Price
- US $79.00-38.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-11-19
- Product
- Side chain for meropenem 96034-64-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-09-21