4-(1H-PYRAZOL-1-YL)BENZYLAMINE

Product Name: 4-(1H-PYRAZOL-1-YL)BENZYLAMINE
CAS No.: 368870-03-5
Chemical Name: 4-(1H-PYRAZOL-1-YL)BENZYLAMINE
Synonyms: AKOS B014367;BUTTPARK 98\50-46;ART-CHEM-BB B014367;ART-CHEM-BB B020480;CHEMBRDG-BB 4003287;4-(1-PYRAZOLYL)BENZYLAMINE;4-PYRAZOL-1-YL-BENZYLAMINE;4-(1H-pyrazol-1-)benzylamine;4-(1H-PYRAZOL-1-YL)BENZYLAMINE;4-(1H-pyrazol-1-yl)benzylamine97%
CBNumber: CB0308452
Molecular Formula: C10H11N3
Formula Weight: 173.21
MOL File: 368870-03-5.mol

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4-(1H-PYRAZOL-1-YL)BENZYLAMINE Property

Melting point:: 94-95°C
Boiling point:: 307.1±25.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 8.89±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C10H11N3/c11-8-9-2-4-10(5-3-9)13-7-1-6-12-13/h1-7H,8,11H2
InChIKey: AVKMXPDYQVKSFF-UHFFFAOYSA-N
SMILES: C1(CN)=CC=C(N2C=CC=N2)C=C1
CAS DataBase Reference: 368870-03-5

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-41-37/38
Safety Statements: 26-36/37/39-39
RIDADR: 2735
Hazard Note: Corrosive
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: P846908
Product name: (4-(1H-Pyrazol-1-yl)phenyl)methanamine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR23296
Product name: [4-(1H-Pyrazol-1-yl)phenyl]methylamine
Packaging: 250mg
Price: $124
Updated: 2021/12/16

AK Scientific

Product number: X2141
Product name: 4-(1H-Pyrazol-1-yl)benzylamine
Packaging: 1g
Price: $131
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-W2
Product name: [4-(1H-Pyrazol-1-yl)phenyl]methylamine
Packaging: 250mg
Price: $136
Updated: 2021/12/16

Apolloscientific

Product number: OR23296
Product name: [4-(1H-Pyrazol-1-yl)phenyl]methylamine
Packaging: 1g
Price: $201
Updated: 2021/12/16

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4-(1H-PYRAZOL-1-YL)BENZYLAMINE Chemical Properties,Usage,Production

Synthesis

25699-83-6

368870-03-5

General procedure for the synthesis of 4-(1H-pyrazolyl)benzenemethanamine from 4-(1H-pyrazolyl)benzonitrile: To 4-(1H-pyrazolyl)benzonitrile (1.46 g, 8.63 mmol) was added a tetrahydrofuran solution (93 ml, 93 mmol) of 1 M borane-tetrahydrofuran complex and heated to reflux. After 16 hours of reaction, methanol (14 ml) was added to the reaction solution, which was subsequently concentrated under reduced pressure. To the residue 6N hydrochloric acid (265 ml) was added and heating to reflux was continued for 3 hours. After completion of the reaction, the solution was concentrated under reduced pressure and a small amount of water was added. The pH was adjusted to 11 with 30% aqueous sodium hydroxide under cooling in an ice bath and subsequently extracted with dichloromethane. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: chloroform:methanol:28% ammonia = 90:10:1, V/V/V), the fraction containing the target compound was collected and concentrated under reduced pressure to afford the title compound 4-(1H-pyrazolyl)benzylamine (1.24 g, 83% yield) as a light yellow solid. Mass spectrum (CI, m/z): 174 (M++1). 1H-NMR spectrum (CDCl3, ppm): 7.91 (dd, J=2.5,0.5Hz, 1H), 7.72 (d, J=1.6Hz, 1H), 7.69-7.63 (m, 2H), 7.44-7.37 (m, 2H), 6.46 (dd, J=2.5, 1.6Hz, 1H). 1.6 Hz, 1H), 3.91 (s, 2H).

References

[1] Patent: EP2264009, 2010, A1. Location in patent: Page/Page column 103
[2] Patent: EP2415763, 2012, A1. Location in patent: Page/Page column 105
[3] Patent: WO2017/87837, 2017, A1. Location in patent: Paragraph 00270
[4] Patent: US2013/123281, 2013, A1. Location in patent: Paragraph 0127
[5] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 231

4-(1H-PYRAZOL-1-YL)BENZYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1H-PYRAZOL-1-YL)BENZYLAMINE Suppliers

Belgium 1 China 72 Germany 4 India 2 Russia 1 United Kingdom 3 United States 12 Global 95

Wuhan Co TC SR Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Syntechem Co.,Ltd

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Thermo Fisher Scientific

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NovoChemy Ltd.

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9ding chemical ( Shanghai) Limited

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Wuhan Kaymke Chemical Co., Ltd.,

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Shanghai Raise Chemical Technology Co.,Ltd

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368870-03-5, 4-(1H-PYRAZOL-1-YL)BENZYLAMINERelated Search:

2-(1H-Pyrazol-1-yl)benzylamine 97%,2-(1H-PYRAZOL-1-YL)BENZYLAMINE 3-PYRAZOL-1-YL-BENZYLAMINE,3-PYRAZOL-1-YL-BENZYLAMINE HCL,3-(1H-PYRAZOL-1-YL)BENZYLAMINE 2-(1-PYRROLYL)BENZYLAMINE Benzylamine N-(3,4-DIMETHOXYPHENYL)-3-NITRO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXAMIDE N-(4-CHLOROPHENYL)-3-NITRO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXAMIDE 3-(1-methyl-1h-pyrazol-5-yl)benzylamine,3-(1-Methyl-1H-pyrazol-5-yl)benzylamine 97% n-methyl-4-(1-methyl-1h-pyrazol-3-yl)benzylamine N-Methyl-2-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzylamine 4-(1-Methyl-1H-pyrazol-3-yl)benzylamine 97%,4-(1-Methyl-1H-pyrazol-3-yl)benzylamine n-methyl-3-(1-methyl-1h-pyrazol-3-yl)benzylamine 3-(1-METHYL-1H-PYRAZOL-3-YL)BENZYLAMINE 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzylamine 97%,4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)BENZYLAMINE 2-[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]Benzylamine 4-[4-(4-CHLOROPHENYL)-1H-PYRAZOL-1-YL]-N-(3-PYRIDINYLMETHYL)BENZAMIDE 4-[4-(4-CHLOROPHENYL)-1H-PYRAZOL-1-YL]-N-(2-METHOXYETHYL)BENZAMIDE N-(3-CHLORO-2-METHYLPHENYL)-3-NITRO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXAMIDE N-(4-METHYLPHENYL)-3-NITRO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXAMIDE

AKOS B014367

4-PYRAZOL-1-YL-BENZYLAMINE

4-(1-PYRAZOLYL)BENZYLAMINE

4-(1H-PYRAZOL-1-YL)BENZYLAMINE

ART-CHEM-BB B020480

ART-CHEM-BB B014367

BUTTPARK 98\50-46

CHEMBRDG-BB 4003287

4-(1H-Pyrazol-1-yl)benzylamine 97%

4-(1H-pyrazol-1-yl)benzylamine97%

1-[4-(1H-pyrazol-1-yl)phenyl]methanamine(SALTDATA: FREE)

[4-(1H-Pyrazol-1-yl)phenyl]methylamine

4-(1H-Pyrazol-1-yl)benzylamine, 1-[4-(Aminomethyl)phenyl]-1H-pyrazole

Benzenemethanamine, 4-(1H-pyrazol-1-yl)-

[4-(1-pyrazolyl)phenyl]methanamine

(4-pyrazol-1-ylphenyl)methanamine

4-(1H-Pyrazol-1-yl)benzenemethanamine

4-(1H-pyrazol-1-)benzylamine

368870-03-5

Aminomethyl's

Phenyls & Phenyl-Het