DPC-681

Product Name: DPC-681
CAS No.: 284661-68-3
Chemical Name: DPC-681
Synonyms: DPC-681;DPH-153893;DPC 681,DPC681;DPC-681 (DPH-153893);L-Valinamide, N-[(3-fluorophenyl)methyl]glycyl-N-[(1S,2R)-3-[[(3-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-
CBNumber: CB03121092
Molecular Formula: C35H48FN5O5S
Formula Weight: 669.85
MOL File: 284661-68-3.mol

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DPC-681 Property

Density: 1.217±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 13.52±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5439
Product name: DPC-681
Purity: 99.72%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5439
Product name: DPC-681
Purity: 99.72%
Packaging: 5mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611409
Product name: DPC-681
Packaging: 5mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-5439
Product name: DPC-681
Purity: 99.72%
Packaging: 10mg
Price: $960
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611409
Product name: DPC-681
Packaging: 10mg
Price: $970.7
Updated: 2021/12/16

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DPC-681 Chemical Properties,Usage,Production

Uses

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. IC50 value: 4 - 40 nM [1] Target: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1] in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1]

IC 50

HIV-1

References

[1] Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. DOI:10.1128/AAC.45.11.3021-3028.2001

DPC-681 Preparation Products And Raw materials

Raw materials

Preparation Products

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DPC-681 Suppliers

China 25 United States 7 Global 32

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284661-68-3, DPC-681Related Search:

DPC-681

DPH-153893

L-Valinamide, N-[(3-fluorophenyl)methyl]glycyl-N-[(1S,2R)-3-[[(3-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-

DPC-681 (DPH-153893)

DPC 681,DPC681

284661-68-3

C35H48FN5O5S