1-BROMO-2-METHOXYNAPHTHALENE
- Product Name
- 1-BROMO-2-METHOXYNAPHTHALENE
- CAS No.
- 3401-47-6
- Chemical Name
- 1-BROMO-2-METHOXYNAPHTHALENE
- Synonyms
- 1-Bromo-2-methoxynapthalene;2-Methoxy-1-naphtyl bromide;1-BROMO-2-METHOXYNAPHTHALENE;Naphthalene, 1-broMo-2-Methoxy-;1-Bromo-2-Naphthalene Methyl Ether;1-Bromo-2-methoxynaphthalene, >=97%
- CBNumber
- CB0312286
- Molecular Formula
- C11H9BrO
- Formula Weight
- 237.09
- MOL File
- 3401-47-6.mol
1-BROMO-2-METHOXYNAPHTHALENE Property
- Melting point:
- 80-83 °C
- Boiling point:
- 190-192 °C(Press: 22 Torr)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- BRN
- 2045600
- InChI
- InChI=1S/C11H9BrO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,1H3
- InChIKey
- XNIGURFWNPLWJM-UHFFFAOYSA-N
- SMILES
- C1(Br)=C2C(C=CC=C2)=CC=C1OC
- CAS DataBase Reference
- 3401-47-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B6103
- Product name
- 1-Bromo-2-methoxynaphthalene
- Packaging
- 5G
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B6103
- Product name
- 1-Bromo-2-methoxynaphthalene
- Packaging
- 25G
- Price
- $188
- Updated
- 2025/07/31
- Product number
- B685775
- Product name
- 1-Bromo-2-methoxy-naphthalene
- Packaging
- 100g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- FB140571
- Product name
- 1-Bromo-2-methoxynaphthalene
- Packaging
- 5G
- Price
- $63
- Updated
- 2021/12/16
- Product number
- Z0523
- Product name
- 1-Bromo-2-methoxynaphthalene
- Packaging
- 5g
- Price
- $91
- Updated
- 2021/12/16
1-BROMO-2-METHOXYNAPHTHALENE Chemical Properties,Usage,Production
Chemical Properties
solid
Uses
1-Bromo-2-methoxy-naphthalene is a useful synthetic intermediate. It is used as a reagent to synthesize a catalyst for highly enantioselective aziridination of styrene derivatives. It can also be used to prepare biaryls or biheterocycles by palladium-catalyzed Ullmann coupling.
Synthesis
573-97-7
74-88-4
3401-47-6
In a 500 mL round-bottomed three-necked flask, 1-bromo-2-naphthol (30.0 g, 134.5 mmol), potassium hydroxide (KOH, 11.3 g, 201.7 mmol) and 300 mL of dimethylsulfoxide (DMSO) were added, and stirred under nitrogen protection for 10 min. Subsequently, the reaction system was cooled in an ice-water bath and iodomethane (28.6 g, 201.7 mmol) was added dropwise slowly. After the dropwise addition, stirring was continued at room temperature under nitrogen atmosphere for 12 h. The reaction was then warmed up to 50 °C for 1 h. The reaction was then completed by cooling to 50 °C for 10 min. After completion of the reaction, it was cooled to room temperature. The reaction mixture was poured into 500 mL of water and extracted with ether. The organic phase was washed three times with distilled water and dried over anhydrous magnesium sulfate (MgSO4). After the solvent was evaporated under reduced pressure, it was purified by silica gel column chromatography (eluent: n-hexane) to afford 1-bromo-2-methoxynaphthalene 22.0 g (yield 69.0%) as a white solid.
References
[1] Patent: KR2016/17530, 2016, A. Location in patent: Paragraph 0238; 0241; 0245; 0246
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 24, p. 4800 - 4818
[3] Journal of Organic Chemistry, 2000, vol. 65, # 5, p. 1511 - 1515
[4] Patent: JP5656843, 2015, B2. Location in patent: Paragraph 0092; 0093
[5] Journal of the Chemical Society, 1900, vol. 77, p. 37
1-BROMO-2-METHOXYNAPHTHALENE Preparation Products And Raw materials
Raw materials
Preparation Products
1-BROMO-2-METHOXYNAPHTHALENE Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 1-BROMO-2-METHOXYNAPHTHALENE manufacturers
- Product
- 1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- 1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-18
- Product
- 1-Bromo-2-methoxynaphthalene 3401-47-6
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31