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evobrutinib

Product Name: evobrutinib
CAS No.: 1415823-73-2
Chemical Name: evobrutinib
Synonyms: M2951;140920;evobrutinib;MSC2364447C;M2951; MSC2364447C;Evobrutinib (M2951);M-2951 (Evobrutinib);evobrutinib, 10 mM in DMSO;1-[4-({[6-Amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino}methyl)-1-piperidinyl]-2-propen-1-one;1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
CBNumber: CB03126648
Molecular Formula: C25H27N5O2
Formula Weight: 429.51
MOL File: 1415823-73-2.mol

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evobrutinib Property

Melting point:: 173 - 174oC
Boiling point:: 683.4±55.0 °C(Predicted)
Density: 1.227±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 5.29±0.10(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29029
Product name: Evobrutinib
Packaging: 1mg
Price: $29
Updated: 2022/04/27

Cayman Chemical

Product number: 29029
Product name: Evobrutinib
Packaging: 25mg
Price: $492
Updated: 2022/04/27

Cayman Chemical

Product number: 29029
Product name: Evobrutinib
Packaging: 5mg
Price: $135
Updated: 2022/04/27

Cayman Chemical

Product number: 29029
Product name: Evobrutinib
Packaging: 10mg
Price: $240
Updated: 2022/04/27

TRC

Product number: E947503
Product name: Evobrutinib
Packaging: 5mg
Price: $190
Updated: 2021/12/16

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evobrutinib Chemical Properties,Usage,Production

Uses

Evobrutinib is a highly selective inhibitor of the Bruton’s tyrosine kinase (BTK), which is important in the -development and functioning of various immune cells including B -lymphocytes and macrophages. Preclinical research suggests it may be therapeutically useful in certain autoimmune diseases.

in vivo

Evobrutinib (0.3, 1, 3, 10, or 30 mg/kg, oral gavage, once daily) demonstrates efficacy in a rat model of rheumatoid arthritis^[1].

Animal Model:	Female Lewis rats with semi-established type II collagen arthritis^[1].
Dosage:	0.3, 1, 3, 10, or 30 mg/kg.
Administration:	Oral gavage once daily for 11 days (days 6-16).
Result:	Reduced ankle histopathology scores in a dose-dependent manner, compared to vehicle.

evobrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from evobrutinib manufacturers

Career Henan Chemica Co

Product: evobrutinib 1415823-73-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

Henan Fengda Chemical Co., Ltd

Product: evobrutinib 1415823-73-2
Price: US $8.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

1415823-73-2, evobrutinibRelated Search:

MSC2364447C

M2951

M2951; MSC2364447C

140920

evobrutinib

1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

1-[4-({[6-Amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino}methyl)-1-piperidinyl]-2-propen-1-one

M-2951 (Evobrutinib)

Evobrutinib (M2951)

2-Propen-1-one, 1-[4-[[[6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino]methyl]-1-piperidinyl]-

evobrutinib, 10 mM in DMSO

1415823-73-2

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