ChemicalBook > CAS DataBase List > PBTZ169

PBTZ169

Product Name
PBTZ169
CAS No.
1377239-83-2
Chemical Name
PBTZ169
Synonyms
CS-2309;Macozinone;PBTZ169 (PBTZ 169;Macozinone(PBTZ169);Macozinone, 10 mM in DMSO;PBTZ169;PBTZ-169;PBTZ 169;2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one; 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-;2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one
CBNumber
CB03128778
Molecular Formula
C20H23F3N4O3S
Formula Weight
456.48
MOL File
1377239-83-2.mol
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PBTZ169 Property

storage temp. 
Store at -20°C
solubility 
DMSO:4.6(Max Conc. mg/mL);10.1(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22202
Product name
PBTZ169
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22202
Product name
PBTZ169
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22202
Product name
PBTZ169
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
22202
Product name
PBTZ169
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
P216563
Product name
PBTZ169
Packaging
5mg
Price
$140
Updated
2021/12/16
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PBTZ169 Chemical Properties,Usage,Production

Description

PBTZ169 is an antibiotic with antimycobacterial activity. It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria. PBTZ169 is active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 μM. It reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis when administered at a dose of 50 mg/kg per day.

Uses

PBTZ169 is a potent irreversible inhibitor of decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1), and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

PBTZ169 Preparation Products And Raw materials

Raw materials

Preparation Products

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PBTZ169 Suppliers

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View Lastest Price from PBTZ169 manufacturers

Career Henan Chemical Co
Product
2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one 1377239-83-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1377239-83-2, PBTZ169Related Search:


  • 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one
  • Macozinone
  • PBTZ169;PBTZ-169;PBTZ 169
  • CS-2309
  • PBTZ169 (PBTZ 169
  • 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
  • 4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-
  • 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one
  • Macozinone(PBTZ169)
  • Macozinone, 10 mM in DMSO
  • 1377239-83-2