FITM
- Product Name
- FITM
- CAS No.
- 932737-65-0
- Chemical Name
- FITM
- Synonyms
- FITM;FITM, 10 mM in DMSO;FITM,mGluR,Metabotropic glutamate receptors,inhibit,Inhibitor;4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide;4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide;4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide;Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-
- CBNumber
- CB03133226
- Molecular Formula
- C18H18FN5OS
- Formula Weight
- 371.43
- MOL File
- 932737-65-0.mol
FITM Property
- Boiling point:
- 573.9±60.0 °C(Predicted)
- Density
- 1.334±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100mM; Ethanol: 20mM
- form
- A crystalline solid
- pka
- 3.03±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29219
- Product name
- FITM
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29219
- Product name
- FITM
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 29219
- Product name
- FITM
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29219
- Product name
- FITM
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 6859
- Product name
- FITM
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $609
- Updated
- 2021/12/16
FITM Chemical Properties,Usage,Production
Uses
4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is a potent mGluR1 antagonist. It also demonstrats a relatively potent antipyschotic-like effect in several animal models, suitable for the development of a PET tracer.
in vivo
The pretreatment of rats with unlabeled FITM (1 mg/kg) occupies an mGluR1 binding site of 18F-FITM by more than 99% and does not affect the input function. The Kd (nM) and Bmax (pmol/mL) obtained by the Scatchard analyses with the multidose ligand assays are 2.1 and 36.3, respectively, for the thalamus; 2.1 and 27.5, respectively, for the hippocampus; 1.5 and 22.2, respectively, for the striatum; and 1.5 and 20.5, respectively, for the cingulate cortex with a high confidence[3]. 18F-FITM shows excellent pharmacokinetics, namely the dense and specific accumulation in mGlu1-positive melanomas versus mGlu1-negative hepatoma and normal tissues. Furthermore, the accumulation levels of radioactivity corresponded to the extent of tumor and to levels of mGlu1 protein expression in melanomas and melanoma metastasis[4].
IC 50
mGlu1: 2.5 nM (Ki)
storage
Store at -20°C
FITM Preparation Products And Raw materials
Raw materials
Preparation Products
FITM Suppliers
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- 86-21-57758967
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- China
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