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FITM

Product Name
FITM
CAS No.
932737-65-0
Chemical Name
FITM
Synonyms
FITM;FITM, 10 mM in DMSO;FITM,mGluR,Metabotropic glutamate receptors,inhibit,Inhibitor;4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide;4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide;4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide;Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-
CBNumber
CB03133226
Molecular Formula
C18H18FN5OS
Formula Weight
371.43
MOL File
932737-65-0.mol
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FITM Property

Boiling point:
573.9±60.0 °C(Predicted)
Density 
1.334±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100mM; Ethanol: 20mM
form 
A crystalline solid
pka
3.03±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29219
Product name
FITM
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29219
Product name
FITM
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
29219
Product name
FITM
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29219
Product name
FITM
Packaging
10mg
Price
$169
Updated
2024/03/01
Tocris
Product number
6859
Product name
FITM
Purity
≥98%(HPLC)
Packaging
50
Price
$609
Updated
2021/12/16
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FITM Chemical Properties,Usage,Production

Uses

4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is a potent mGluR1 antagonist. It also demonstrats a relatively potent antipyschotic-like effect in several animal models, suitable for the development of a PET tracer.

in vivo

The pretreatment of rats with unlabeled FITM (1 mg/kg) occupies an mGluR1 binding site of 18F-FITM by more than 99% and does not affect the input function. The Kd (nM) and Bmax (pmol/mL) obtained by the Scatchard analyses with the multidose ligand assays are 2.1 and 36.3, respectively, for the thalamus; 2.1 and 27.5, respectively, for the hippocampus; 1.5 and 22.2, respectively, for the striatum; and 1.5 and 20.5, respectively, for the cingulate cortex with a high confidence[3]. 18F-FITM shows excellent pharmacokinetics, namely the dense and specific accumulation in mGlu1-positive melanomas versus mGlu1-negative hepatoma and normal tissues. Furthermore, the accumulation levels of radioactivity corresponded to the extent of tumor and to levels of mGlu1 protein expression in melanomas and melanoma metastasis[4].

IC 50

mGlu1: 2.5 nM (Ki)

storage

Store at -20°C

FITM Preparation Products And Raw materials

Raw materials

Preparation Products

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FITM Suppliers

China 54 United States 6 Global 60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

932737-65-0, FITMRelated Search:

METHYL-(3-PHENYL-PROPYL)-AMINE N-Isopropylbenzylamine N-Nitrosodibutylamine N-Methyl-2-pyrrolidone

  • FITM
  • 4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
  • Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-
  • 4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide
  • FITM,mGluR,Metabotropic glutamate receptors,inhibit,Inhibitor
  • 4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide
  • FITM, 10 mM in DMSO
  • 932737-65-0