TPO agonist 1

Product Name: TPO agonist 1
CAS No.: 1033040-23-1
Chemical Name: TPO agonist 1
Synonyms: TPO agonist 1;1H-Pyrazole-4,5-dione, 1-(3,4-dimethylphenyl)-3-methyl-, 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone]
CBNumber: CB03133352
Molecular Formula: C25H22N8O2
Formula Weight: 466.49
MOL File: 1033040-23-1.mol

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TPO agonist 1 Property

Boiling point:: 703.5±70.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
pka: 4.25±0.10(Predicted)
form: Solid
color: Pink to red

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H301Toxic if swalloed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5711
Product name: TPOagonist1
Purity: 95.58%
Packaging: 2mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-5711
Product name: TPOagonist1
Purity: 95.58%
Packaging: 5mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-5711
Product name: TPOagonist1
Purity: 95.58%
Packaging: 10mg
Price: $264
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611477
Product name: TPO-Agonist-1
Packaging: 5mg
Price: $306
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611477
Product name: TPO-Agonist-1
Packaging: 10mg
Price: $368.9
Updated: 2021/12/16

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TPO agonist 1 Chemical Properties,Usage,Production

Uses

TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia[1].

Biological Activity

TPO agonist 1 is a TPO agonist that acts as a promoter of thrombopoiesis and megakaryocytopoiesis for the study of thrombocytopenia.

in vivo

The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes, and can increases platelet counts, decrease bleeding events and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis^[2].

target

TPO receptor

References

[1] Jerome Francis Hayes. Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics. 6 November 2008. WO2008134338A1.
[2] Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia. et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21 DOI:10.1053/j.seminhematol.2013.03.005

TPO agonist 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TPO agonist 1 Suppliers

China 23 United States 5 Global 28

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1033040-23-1, TPO agonist 1Related Search:

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TPO agonist 1

1H-Pyrazole-4,5-dione, 1-(3,4-dimethylphenyl)-3-methyl-, 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone]

1033040-23-1