ChemicalBook > CAS DataBase List > BAY-1143572.

BAY-1143572.

Product Name
BAY-1143572.
CAS No.
1414943-88-6
Chemical Name
BAY-1143572.
Synonyms
BAY1143572;BAY 1143572;BAY-1143572.;Atuveciclib Racemate;BAY-1143572 Racemate;Atuveciclib(BAY-1143572);ATUVECICLIB RACEMATE (BAY-1143572 RACEMATE);4-(4-fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(S-methylsulfonimidoyl)methyl]phenyl]-;(rac)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine
CBNumber
CB03133468
Molecular Formula
C18H18FN5O2S
Formula Weight
387.43
MOL File
1414943-88-6.mol
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BAY-1143572. Property

Boiling point:
589.9±60.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 125 mg/mL (322.64 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6307
Product name
AtuveciclibRacemate
Purity
98.48%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-6307
Product name
AtuveciclibRacemate
Purity
98.48%
Packaging
10mg
Price
$850
Updated
2021/12/16
DC Chemicals
Product number
DC10376
Product name
BAY-1143572
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
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BAY-1143572. Chemical Properties,Usage,Production

Biological Activity

Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 of 13 nM for CDK9/CycT. Its IC50 for CDK2 is about 100-fold higher than that for CDK9. In addition to CDK family members, it also inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β, respectively.

in vivo

BAY 1143572 has a low plasma clearance (CL b 1.1 L/h/kg) and a volume of distribution (Vss) of 1.0 L/kg in a rat pharmacokinetic study . Its oral bioavailability is 54% and the blood-plasma concentration ratio is 1. BAY 1143572 has no significant inhibitory effect on cytochrome P450 activity, IC50>20 μM. NOD/Shi-scid/IL-2Rγ in immunocompromised.

target

TargetValue
CDK9
(Cell-free assay)		 13 nM
GSK-3α
()		 45 nM
GSK3β
()		 87 nM

BAY-1143572. Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1143572. Suppliers

China 43 United States 3 USA 1 Global 47

1414943-88-6, BAY-1143572.Related Search:


  • BAY 1143572
  • BAY1143572
  • ATUVECICLIB RACEMATE (BAY-1143572 RACEMATE)
  • Atuveciclib Racemate
  • Atuveciclib(BAY-1143572)
  • (rac)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine
  • 4-(4-fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-1,3,5-triazin-2-amine
  • BAY-1143572.
  • BAY-1143572 Racemate
  • 1,3,5-Triazin-2-amine, 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(S-methylsulfonimidoyl)methyl]phenyl]-
  • Atuveciclib,BAY1143572,Cyclin dependent kinase,inhibit,Inhibitor,CDK,Atuveciclib Racemate,BAY 1143572,BAY-1143572
  • 1414943-88-6