ChemicalBook > CAS DataBase List > NS-018 (maleate)

NS-018 (maleate)

Product Name
NS-018 (maleate)
CAS No.
1354799-87-3
Chemical Name
NS-018 (maleate)
Synonyms
NS-018 (maleate);Ilginatinib maleate;Ilginatinib (NS-018) maleate;NS018 MALEATE;ILGINATINIB MALEATE;Ilginatinib maleate, 10 mM in DMSO;ILGINATINIB (MALEATE) (NS-018 (MALEATE));(S)-N2-(1-(4-Fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate;Inhibitor,JAK3,NS 018,inhibit,JAK2,Ilginatinib,bioavailable,NS018,orally,Ilginatinib maleate,NS-018,JAK1,Janus kinase,JAK,Tyk2
CBNumber
CB03137709
Molecular Formula
C25H24FN7O4
Formula Weight
505.5009632
MOL File
1354799-87-3.mol
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NS-018 (maleate) Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 30 mg/mL (59.35 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5784
Product name
Ilginatinibmaleate
Purity
97.04%
Packaging
5mg
Price
$285
Updated
2021/12/16
ChemScene
Product number
CS-5784
Product name
Ilginatinibmaleate
Purity
97.04%
Packaging
10mg
Price
$395
Updated
2021/12/16
ChemScene
Product number
CS-5784
Product name
Ilginatinibmaleate
Purity
97.04%
Packaging
25mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-5784
Product name
Ilginatinibmaleate
Purity
97.04%
Packaging
50mg
Price
$870
Updated
2021/12/16
ChemScene
Product number
CS-5784
Product name
Ilginatinibmaleate
Purity
97.04%
Packaging
100mg
Price
$1250
Updated
2021/12/16
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NS-018 (maleate) Chemical Properties,Usage,Production

Uses

Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).

Biological Activity

Ilginatinib maleate (NS-018 maleate) is a highly potent, orally available JAK2 inhibitor with IC50 of 0.72 nM, 46-fold selectivity for JAK1 (IC50, 33 nM) and 54-fold for JAK3 ( IC50, 39 nM), and 22 times that of Tyk2 (IC50, 22 nM).

in vivo

Ilginatinib maleate (NS-018 maleate) (12.5, 25, 50, 100 mg/kg, p.o.) potently prolongs the survival of mice and reduces splenomegaly in a mouse Ba/F3-JAK2V617F disease model.

target

JAK2

0.72 nM (IC 50 )

Tyk2

22 nM (IC 50 )

JAK1

33 nM (IC 50 )

JAK3

39 nM ( IC 50 )

IC 50

JAK2: 0.72 nM (IC50); Tyk2: 22 nM (IC50); JAK1: 33 nM (IC50); JAK3: 39 nM (IC50)

References

[1] Nakaya Y, et al. Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms. Blood Cancer J. 2011 Jul;1(7):e29. DOI:10.1038/bcj.2011.29
[2] Kuroda J, et al. NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients. Leuk Res. 2014 May;38(5):619-24. DOI:10.1016/j.leukres.2014.03.001

NS-018 (maleate) Preparation Products And Raw materials

Raw materials

Preparation Products

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NS-018 (maleate) Suppliers

China 28 United States 5 Global 33
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
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60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1141
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58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
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58

1354799-87-3, NS-018 (maleate)Related Search:


  • NS-018 (maleate)
  • Ilginatinib maleate
  • NS018 MALEATE;ILGINATINIB MALEATE
  • ILGINATINIB (MALEATE) (NS-018 (MALEATE))
  • Inhibitor,JAK3,NS 018,inhibit,JAK2,Ilginatinib,bioavailable,NS018,orally,Ilginatinib maleate,NS-018,JAK1,Janus kinase,JAK,Tyk2
  • (S)-N2-(1-(4-Fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate
  • Ilginatinib maleate, 10 mM in DMSO
  • Ilginatinib (NS-018) maleate
  • 1354799-87-3