DM1-Sme

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Product Name: DM1-Sme
CAS No.: 138148-68-2
Chemical Name: DM1-Sme
Synonyms: DM1-Sme;CS-2715;DM1-SSMe;AP3 Intermidate 2;MaytansinoidDM4Impurity6;1H-Inden-2-ol,1-amino-2,3-dihydro-,(1R,4S)-;N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine;Maytansine, N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]-;4,24-Dioxa-9,22-diazatetracyclo[19.3.1.1 10,14.03,5]hexacosane,maytansine deriv.;maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative
CBNumber: CB03139071
Molecular Formula: C36H50ClN3O10S2
Formula Weight: 784.38
MOL File: 138148-68-2.mol

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DM1-Sme Property

Boiling point:: 957.1±65.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:12.0(Max Conc. mg/mL);15.3(Max Conc. mM)
DMF:16.0(Max Conc. mg/mL);20.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
form: A crystalline solid
pka: 9.82±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H303May be harmfulif swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22477
Product name: DM1-SMe
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 22477
Product name: DM1-SMe
Purity: ≥98%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 22477
Product name: DM1-SMe
Purity: ≥98%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 22477
Product name: DM1-SMe
Purity: ≥98%
Packaging: 25mg
Price: $638
Updated: 2024/03/01

DC Chemicals

Product number: DC11396
Product name: DM1-SMe
Purity: >98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DM1-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

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138148-68-2, DM1-SmeRelated Search:

DM1-Sme

N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine

AP3 Intermidate 2

CS-2715

DM1-SME; DM1-SSME; MAYTANSINOID DERIVATIVE WITH ADC LINKER. MAYTANSINE OR MERTANSINE OR EMTANSINE DERIVATIVE; N2'-DEACETYL-N2'-[3-(METHYLDITHIO)-1-OXOPROPYL]MAYTANSINE.

DM1-SSMe

maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative

Maytansine, N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]-

4,24-Dioxa-9,22-diazatetracyclo[19.3.1.1 10,14.03,5]hexacosane,maytansine deriv.

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methyldisulfaneyl)propanoyl)-L-alaninate

MaytansinoidDM4Impurity6

1H-Inden-2-ol,1-amino-2,3-dihydro-,(1R,4S)-

Microtubule/Tubulin,ADC Payload,anti-tumor activity,tumor cell,DM1 SMe,DM1-SMe,inhibit,Inhibitor,maytansinoid,ADC Cytotoxin,DM-1-SMe,antibody-drug conjugate,DM1SMe

(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl (2S)-2-[N-methyl-3-(methyldisulfanyl)propanamido]propanoate

138148-68-2

C36H50ClN3O10S2