ChemicalBook > CAS DataBase List > (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine

(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine

Product Name: (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
CAS No.: 1815613-42-3
Chemical Name: (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
Synonyms: LX-9211;EOS-61829;BMS-986176;Pilavapadin;BMS-986176 ，E0498;BMS-986176( LX-9211);BMS-986176, 10 mM in DMSO;(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine;(2S)-1-{[2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl]oxy}-2,4-dimethylpentan-2-amine;2-Pentanamine, 1-[[2',6-bis(difluoromethyl)[2,4'-bipyridin]-5-yl]oxy]-2,4-dimethyl-, (2S)-
CBNumber: CB03142383
Molecular Formula: C19H23F4N3O
Formula Weight: 385.4
MOL File: 1815613-42-3.mol

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(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Property

Boiling point:: 470.8±45.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 220 mg/mL (570.84 mM; Need ultrasonic)
form: Solid
pka: 9.23±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Chemical Properties,Usage,Production

Uses

BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1].

References

[1] Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.
[2] Guanglin Luo, et al. Discovery of ( S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65(6):4457-4480. DOI:10.1021/acs.jmedchem.1c02131

(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1815613-42-3, (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amineRelated Search:

(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine

EOS-61829

BMS-986176

LX-9211

BMS-986176( LX-9211)

Inhibitor,BMS-986176,LX9211,AAK-1-IN-1,AAK1,BMS 986176,LX-9211,inhibit,neurodegenerative,LX 9211,BMS986176

(2S)-1-[[2-(difluoromethyl)-6-[2-(difluoromethyl)-4-pyridyl]-3-pyridyl]oxy]-2,4-dimethyl-pentan-2-amine

2-Pentanamine, 1-[[2',6-bis(difluoromethyl)[2,4'-bipyridin]-5-yl]oxy]-2,4-dimethyl-, (2S)-

(2S)-1-{[2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl]oxy}-2,4-dimethylpentan-2-amine

BMS-986176, 10 mM in DMSO

BMS-986176 ，E0498

Pilavapadin

1815613-42-3