ChemicalBook > CAS DataBase List > 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

Product Name
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
CAS No.
1399177-37-7
Chemical Name
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
Synonyms
TVB-2640;TVB2640;ASC40;ASC 40;ASC-40;EOS-61292;FASN-IN-2;Denifanstat;FASN inhibitor 2;TVB-2640(FASN-IN-2)
CBNumber
CB03142727
Molecular Formula
C27H29N5O
Formula Weight
439.55
MOL File
1399177-37-7.mol
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4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Property

Boiling point:
708.3±70.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
solubility 
DMSO: soluble
form 
A solid
pka
9.96±0.40(Predicted)
color 
White to off-white
InChIKey
BBGOSBDSLYHMRA-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(C2CCN(C(=O)C3=CC(C4NN=C(C)N=4)=C(C4CCC4)C=C3C)CC2)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0066310
Product name
FASN-IN-2
Purity
98.52%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0066310
Product name
FASN-IN-2
Purity
98.52%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0066310
Product name
FASN-IN-2
Purity
98.52%
Packaging
50mg
Price
$1500
Updated
2021/12/16
DC Chemicals
Product number
DC26189
Product name
TVB-2640
Packaging
250mg
Price
$1700
Updated
2021/12/16
DC Chemicals
Product number
DC26189
Product name
TVB-2640
Packaging
100mg
Price
$950
Updated
2021/12/16
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4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Chemical Properties,Usage,Production

Uses

Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2].

References

[1] Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.
[2] Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Suppliers

China 66 United States 4 Global 70
Wuhan HSN Pharmaresearch CO., LTD.
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027-81525288 18086100502
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linwell@126.com
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China
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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17702719238 18971495150;
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sales@sun-shinechem.com
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China
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Shanghai XingMo Biotechnology Co., Ltd.
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+86 13524779951; 13524779951
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Shanghai Lollane Biological Technology Co.,Ltd.
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ShangHai Biochempartner Co.,Ltd
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1399177-37-7, 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrileRelated Search:


  • 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
  • EOS-61292
  • TVB2640
  • TVB-2640
  • FASN-IN-2
  • FASN inhibitor 2
  • Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-
  • Denifanstat
  • Denifanstat (TVB-2640)
  • SARS-CoV2,ASC40,Denifanstat,TVB 2640,Inhibitor,spike,inhibit,ASC 40,Fatty Acid Synthase (FASN),protein,COVID-19,ASC-40
  • TVB-2640(FASN-IN-2)
  • ASC 40
  • ASC40
  • ASC-40
  • 4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile
  • Denifanstat, 10 mM in DMSO
  • 1399177-37-7
  • TVB2640