4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine

Product Name: 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
CAS No.: 1401436-95-0
Chemical Name: 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
Synonyms: PWT-143;EOS-60789;Zandelisib;Zandelisib, 10 mM in DMSO;4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine;4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[1,1-dimethyl-2-[2-(1-methyl-4-piperidinyl)phenyl]ethyl]-6-(4-morpholinyl)-;4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-N-{2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine;PWT143,3-kinase,Phosphatidylinositol,Zandelisib,inhibit,ME401,Phosphoinositide 3-kinase,PWT-143,PWT 143,antineoplastic,PI3K,ME-401,ME 401,Inhibitor,p110δ
CBNumber: CB03142732
Molecular Formula: C31H38F2N8O
Formula Weight: 576.6832264
MOL File: 1401436-95-0.mol

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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Property

Boiling point:: 729.2±70.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 33.33 mg/mL (57.80 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
pka: 8.97±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0119144
Product name: Zandelisib
Purity: 98.79%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0119144
Product name: Zandelisib
Purity: 98.79%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0119144
Product name: Zandelisib
Purity: 98.79%
Packaging: 25mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0119144
Product name: Zandelisib
Purity: 98.79%
Packaging: 50mg
Price: $3000
Updated: 2021/12/16

ChemScene

Product number: CS-0119144
Product name: Zandelisib
Purity: 98.79%
Packaging: 100mg
Price: $4600
Updated: 2021/12/16

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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Chemical Properties,Usage,Production

Uses

Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic[1][2].

IC 50

PI3Kδ: 3.5 nM (IC₅₀)

References

[1] Daniel P. Gold, et al. Combination therapy. WO2019183226A1.
[2] David Brown, et al. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases. WO2014055647A1.

4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Suppliers

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1401436-95-0, 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amineRelated Search:

4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine

EOS-60789

PWT-143

Zandelisib

1,3,5-Triazin-2-amine, 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[1,1-dimethyl-2-[2-(1-methyl-4-piperidinyl)phenyl]ethyl]-6-(4-morpholinyl)-

4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-N-{2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine

4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine

PWT143,3-kinase,Phosphatidylinositol,Zandelisib,inhibit,ME401,Phosphoinositide 3-kinase,PWT-143,PWT 143,antineoplastic,PI3K,ME-401,ME 401,Inhibitor,p110δ

Zandelisib, 10 mM in DMSO

1401436-95-0

C31H38F2N8O