ChemicalBook > CAS DataBase List > 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine

4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine

Product Name
4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
CAS No.
1401436-95-0
Chemical Name
4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
Synonyms
PWT-143;EOS-60789;Zandelisib;Zandelisib, 10 mM in DMSO;4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine;4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[1,1-dimethyl-2-[2-(1-methyl-4-piperidinyl)phenyl]ethyl]-6-(4-morpholinyl)-;4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-N-{2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine;PWT143,3-kinase,Phosphatidylinositol,Zandelisib,inhibit,ME401,Phosphoinositide 3-kinase,PWT-143,PWT 143,antineoplastic,PI3K,ME-401,ME 401,Inhibitor,p110δ
CBNumber
CB03142732
Molecular Formula
C31H38F2N8O
Formula Weight
576.6832264
MOL File
1401436-95-0.mol
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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Property

Boiling point:
729.2±70.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (57.80 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
pka
8.97±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0119144
Product name
Zandelisib
Purity
98.79%
Packaging
5mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0119144
Product name
Zandelisib
Purity
98.79%
Packaging
10mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0119144
Product name
Zandelisib
Purity
98.79%
Packaging
25mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-0119144
Product name
Zandelisib
Purity
98.79%
Packaging
50mg
Price
$3000
Updated
2021/12/16
ChemScene
Product number
CS-0119144
Product name
Zandelisib
Purity
98.79%
Packaging
100mg
Price
$4600
Updated
2021/12/16
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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Chemical Properties,Usage,Production

Uses

Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic[1][2].

IC 50

PI3Kδ: 3.5 nM (IC50)

References

[1] Daniel P. Gold, et al. Combination therapy. WO2019183226A1.
[2] David Brown, et al. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases. WO2014055647A1.

4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine Suppliers

China 34 United States 3 Global 37
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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Aladdin Scientific
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United States
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1401436-95-0, 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amineRelated Search:


  • 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
  • EOS-60789
  • PWT-143
  • Zandelisib
  • 1,3,5-Triazin-2-amine, 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[1,1-dimethyl-2-[2-(1-methyl-4-piperidinyl)phenyl]ethyl]-6-(4-morpholinyl)-
  • 4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-N-{2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine
  • 4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine
  • PWT143,3-kinase,Phosphatidylinositol,Zandelisib,inhibit,ME401,Phosphoinositide 3-kinase,PWT-143,PWT 143,antineoplastic,PI3K,ME-401,ME 401,Inhibitor,p110δ
  • Zandelisib, 10 mM in DMSO
  • 1401436-95-0
  • C31H38F2N8O