YKL-05-099

Product Name: YKL-05-099
CAS No.: 1936529-65-5
Chemical Name: YKL-05-099
Synonyms: YKL-05-099;YKL-05-099, 10 mM in DMSO;YKL05099,YKL 05 099,inhibit,Salt-inducible Kinase (SIK),Inhibitor;3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-
CBNumber: CB03147616
Molecular Formula: C32H34ClN7O3
Formula Weight: 600.11
MOL File: 1936529-65-5.mol

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YKL-05-099 Property

Boiling point:: 761.0±70.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO:103.33(Max Conc. mg/mL);172.18(Max Conc. mM)
form: A solid
pka: 8.63±0.20(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6458
Product name: YKL-05-099
Purity: 99.76%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-6458
Product name: YKL-05-099
Purity: 99.76%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6458
Product name: YKL-05-099
Purity: 99.76%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6458
Product name: YKL-05-099
Purity: 99.76%
Packaging: 50mg
Price: $2220
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611258
Product name: YKL-05-099
Purity: >98%
Packaging: 100mg
Price: $2245.7
Updated: 2021/12/16

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YKL-05-099 Chemical Properties,Usage,Production

Biological Activity

Potent and selective salt-inducible kinases (SIK1, SIK2, SIK3) inhibitor in vitro and in vivo.

YKL-05-099 is a potent and selective salt-inducible kinases inhibitor (SIK1/2/3 IC50 = 10/40/30 nM) with superior pharmacokinetic properties than HG-9-91-01. YKL-05-099 pre-treatment of murine BDMCs up-regulates Zymosan A-stimulated IL-10 (EC50 = 460 nM with 24h ), while suppresses inflammatory cytokines production (TNFα, IL-6 and IL-12p40). Likewise, YKL-05-099 intraperitoneal administration in mice (20 mg/kg i.p.) 15 min prior to LPS (0.5 mg/kg i.p.) enhances serum IL-10, while reduces HDAC5 pSer259 levels in total splenic leukocytes and serum TNFα level in vivo.

YKL-05-099 Preparation Products And Raw materials

Raw materials

Preparation Products

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YKL-05-099 Suppliers

China 48 India 1 United States 4 USA 1 Global 54

ChemCell Biomedicine Co.,Ltd.

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Fax: +86-21-52996696
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Shanghai Chaolan Chemical Technology Center

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Zhengzhou Acme Chemical Co., Ltd.

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1936529-65-5, YKL-05-099Related Search:

YKL 06-061 YKL-06-062 YKL-5-124

YKL-05-099

Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-

3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

YKL05099,YKL 05 099,inhibit,Salt-inducible Kinase (SIK),Inhibitor

YKL-05-099, 10 mM in DMSO

1936529-65-5