YKL-05-099
- Product Name
- YKL-05-099
- CAS No.
- 1936529-65-5
- Chemical Name
- YKL-05-099
- Synonyms
- YKL-05-099;YKL-05-099, 10 mM in DMSO;YKL05099,YKL 05 099,inhibit,Salt-inducible Kinase (SIK),Inhibitor;3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-
- CBNumber
- CB03147616
- Molecular Formula
- C32H34ClN7O3
- Formula Weight
- 600.11
- MOL File
- 1936529-65-5.mol
YKL-05-099 Property
- Boiling point:
- 761.0±70.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO:103.33(Max Conc. mg/mL);172.18(Max Conc. mM)
- form
- A solid
- pka
- 8.63±0.20(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-6458
- Product name
- YKL-05-099
- Purity
- 99.76%
- Packaging
- 10mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-6458
- Product name
- YKL-05-099
- Purity
- 99.76%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-6458
- Product name
- YKL-05-099
- Purity
- 99.76%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-6458
- Product name
- YKL-05-099
- Purity
- 99.76%
- Packaging
- 50mg
- Price
- $2220
- Updated
- 2021/12/16
- Product number
- orb611258
- Product name
- YKL-05-099
- Purity
- >98%
- Packaging
- 100mg
- Price
- $2245.7
- Updated
- 2021/12/16
YKL-05-099 Chemical Properties,Usage,Production
Biological Activity
Potent and selective salt-inducible kinases (SIK1, SIK2, SIK3) inhibitor in vitro and in vivo.
YKL-05-099 is a potent and selective salt-inducible kinases inhibitor (SIK1/2/3 IC50 = 10/40/30 nM) with superior pharmacokinetic properties than HG-9-91-01. YKL-05-099 pre-treatment of murine BDMCs up-regulates Zymosan A-stimulated IL-10 (EC50 = 460 nM with 24h ), while suppresses inflammatory cytokines production (TNFα, IL-6 and IL-12p40). Likewise, YKL-05-099 intraperitoneal administration in mice (20 mg/kg i.p.) 15 min prior to LPS (0.5 mg/kg i.p.) enhances serum IL-10, while reduces HDAC5 pSer259 levels in total splenic leukocytes and serum TNFα level in vivo.
YKL-05-099 Preparation Products And Raw materials
Raw materials
Preparation Products
YKL-05-099 Suppliers
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- United States
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