Acumapimod (BCT-197)
- Product Name
- Acumapimod (BCT-197)
- CAS No.
- 836683-15-9
- Chemical Name
- Acumapimod (BCT-197)
- Synonyms
- BCT-197;CS-2801;BCT-197-A2201;Acumapimod (BCT-197);Ixazomib Impurity 62;Acumapimod, 10 mM in DMSO;inhibit,p38 MAPK,BCT197,BCT 197,Acumapimod,Inhibitor,Autophagy;3-(5-Amino-4-(3-cyanobenzoyl)pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide;3-(5-Amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide;Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-
- CBNumber
- CB03147661
- Molecular Formula
- C22H19N5O2
- Formula Weight
- 385.42
- MOL File
- 836683-15-9.mol
Acumapimod (BCT-197) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);129.73(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- InChI
- InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)
- InChIKey
- VGUSQKZDZHAAEE-UHFFFAOYSA-N
- SMILES
- C(NC1CC1)(=O)C1=CC=C(C)C(N2C(N)=C(C(=O)C3=CC=CC(C#N)=C3)C=N2)=C1
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25832
- Product name
- Acumapimod
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 25832
- Product name
- Acumapimod
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 25832
- Product name
- Acumapimod
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 25832
- Product name
- Acumapimod
- Packaging
- 25mg
- Price
- $645
- Updated
- 2024/03/01
- Product number
- CS-6195
- Product name
- Acumapimod
- Purity
- 99.03%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
Acumapimod (BCT-197) Chemical Properties,Usage,Production
Uses
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
in vivo
Acumapimod is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of Acumapimod (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].
References
[1] Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. DOI:10.1517/13543784.2014.918604
[2] De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700. DOI:10.1002/psp4.12037
Acumapimod (BCT-197) Preparation Products And Raw materials
Raw materials
Preparation Products
Acumapimod (BCT-197) Suppliers
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4941
- Advantage
- 55
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2966
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4768
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1944
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58