ChemicalBook > CAS DataBase List > BFH772

BFH772

Product Name
BFH772
CAS No.
890128-81-1
Chemical Name
BFH772
Synonyms
BFH772;CS-2412;Bfh-722;BFH-772; BFH 772;6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide;inhibit,BFH 772,VEGFR,BFH-772,BFH772,Vascular endothelial growth factor receptor,Inhibitor;1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
CBNumber
CB03147777
Molecular Formula
C23H16F3N3O3
Formula Weight
439.39
MOL File
890128-81-1.mol
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BFH772 Property

Boiling point:
541.2±50.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A crystalline solid
pka
12.65±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21386
Product name
BFH-772
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21386
Product name
BFH-772
Packaging
5mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
21386
Product name
BFH-772
Packaging
10mg
Price
$292
Updated
2024/03/01
Cayman Chemical
Product number
21386
Product name
BFH-772
Packaging
25mg
Price
$593
Updated
2024/03/01
ApexBio Technology
Product number
B6199
Product name
BFH772
Packaging
50mg
Price
$709
Updated
2021/12/16
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BFH772 Chemical Properties,Usage,Production

Description

BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor). It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.

in vitro

bfh772 was highly effective at targeting vegfr2 kinase, however, lost 500-fold potency on flk-1, flt-1, and flt-4. bfh772 also targeted b-raf, ret, and tie-2, albeit with at least 40-fold lower potency. bfh772 inhibited the ligand induced autophosphorylation of ret, pdgfr, and kit kinases. bfh772 was selective against the kinases of egfr, erbb2, ins-r, and igf-1r and against the cytoplasmic bcr-abl kinase [1].

in vivo

the dose response curves of bfh772 at 0.3, 1, and 3 mg/kg showed that even at the lowest concentrations, this naphthalene-1-carboxamide inhibited vegf induced tissue weight and tie-2 levels but only reached statistical significance at 1 mg/kg and above. moreover, bfh772 at 3 mg/kg orally dosed once per day could potently inhibit melanoma growth (54-90% for primary tumor and 71-96% for metastasis tumor) when compared with control ratios [1].

IC 50

3 nm

References

[1] bold g, et al. a novel potent oral series of vegfr2 inhibitors abrogate tumor growth by inhibiting angiogenesis. j med chem. 2016 jan 14;59(1):132-46.
[2] http://adisinsight. springer.com/trials/700244037

BFH772 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BFH772 manufacturers

Career Henan Chemical Co
Product
BFH772 890128-81-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

890128-81-1, BFH772Related Search:


  • BFH772
  • Bfh-722
  • CS-2412
  • BFH-772; BFH 772
  • 1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
  • 6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
  • inhibit,BFH 772,VEGFR,BFH-772,BFH772,Vascular endothelial growth factor receptor,Inhibitor
  • 890128-81-1