Momelotinib Dihydrochloride

Product Name: Momelotinib Dihydrochloride
CAS No.: 1380317-28-1
Chemical Name: Momelotinib Dihydrochloride
Synonyms: Cyt387.HCl;Momelotinib 2HC;Momelotinib HCl;Momelotinib 2HCl;Momelotinib Dihydrochloride;Momelotinib Dihydrochloride Monohydrate;N-(Cyanomethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamide.HCl;N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide dihydrochloride
CBNumber: CB03152205
Molecular Formula: C23H23ClN6O2
Formula Weight: 450.93
MOL File: 1380317-28-1.mol

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Momelotinib Dihydrochloride Property

InChIKey: NGOUSYFDVUVHDA-UHFFFAOYSA-N
SMILES: N(C1C=CC(N2CCOCC2)=CC=1)C1=NC=CC(C2C=CC(C(=O)NCC#N)=CC=2)=N1.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Chemenu

Product number: CM337224
Product name: N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide;dihydrochloride
Purity: 95%+
Packaging: 100mg
Price: $471
Updated: 2021/12/16

Chemenu

Product number: CM337224
Product name: N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide;dihydrochloride
Purity: 95%+
Packaging: 250mg
Price: $807
Updated: 2021/12/16

Chemenu

Product number: CM337224
Product name: N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide;dihydrochloride
Purity: 95%+
Packaging: 1g
Price: $2334
Updated: 2021/12/16

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Momelotinib Dihydrochloride Chemical Properties,Usage,Production

Uses

Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis[1].

IC 50

JAK1; JAK2

References

[1] Tremblay D, et al. Momelotinib for the treatment of myelofibrosis with anemia. Future Oncol. 2022 Jun;18(20):2559-2571. DOI:10.2217/fon-2022-0276

Momelotinib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Momelotinib Dihydrochloride Suppliers

China 50 United Kingdom 1 United States 1 Global 52

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 492
Advantage: 55

JIANGXI HANHE PHARMACEUTICAL CO.,LTD

Tel: 13122341786
Email: zhiyang.wang@acebright.com
Country: China
ProdList: 117
Advantage: 58

Arizest(Shanghai)Pharmatech Co.,Ltd

Tel: 18109805911
Email: yu.yang@arizest.com
Country: China
ProdList: 519
Advantage: 58

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: 021-36680027 15821745250
Email: fengqiang@famobiotech.com
Country: China
ProdList: 485
Advantage: 56

Chengdu Yontinotech Co.,Ltd

Tel: 028-86293627 15228898511
Fax: 028-86293627
Email: sales@yontinotech.com
Country: China
ProdList: 106
Advantage: 56

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Email: enkepharma@126.com;sale@enkepharma.com
Country: China
ProdList: 2335
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

JINAN SHENGQI PHARMACEUTICAL CO., LTD

Tel: 0531-88892685 18660160628
Email: 15069007290@163.com
Country: China
ProdList: 183
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

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View Lastest Price from Momelotinib Dihydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Momelotinib Dihydrochloride 1380317-28-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-16

1380317-28-1, Momelotinib DihydrochlorideRelated Search:

Momelotinib Dihydrochloride

Momelotinib 2HCl

Momelotinib HCl

N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide dihydrochloride

Cyt387.HCl

Momelotinib Dihydrochloride Monohydrate

N-(Cyanomethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamide.HCl

Momelotinib 2HC

1380317-28-1