9-PAHSA
- Product Name
- 9-PAHSA
- CAS No.
- 1481636-31-0
- Chemical Name
- 9-PAHSA
- Synonyms
- 9-PAHSA;MHQWHZLXDBVXML-UHFFFAOYSA-N;9-[(1-oxohexadecyl)oxy]-octadecanoicacid;Octadecanoic acid, 9-[(1-oxohexadecyl)oxy]-
- CBNumber
- CB03152528
- Molecular Formula
- C34H66O4
- Formula Weight
- 538.89
- MOL File
- 1481636-31-0.mol
9-PAHSA Property
- Boiling point:
- 619.2±38.0 °C(Predicted)
- Density
- 0.916±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- pka
- 4.78±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 17037
- Product name
- 9-PAHSA
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 17037
- Product name
- 9-PAHSA
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 17037
- Product name
- 9-PAHSA
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 0427DW
- Product name
- 9-Pahsa
- Packaging
- 5mg
- Price
- $398
- Updated
- 2021/12/16
9-PAHSA Chemical Properties,Usage,Production
Description
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-
Uses
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as white and brown adipose tissues of glucose tolerant AG4OX mice, which overexpress Glut4 specifically in adipose tissue. 9-PAHSA is the predominant isomer of PAHSA in wild type and AG4OX mice. It is found in humans and is reduced in the serum and adipose tissues of insulin-resistant humans. 9-PAHSA improves glucose tolerance, stimulates insulin secretion, and has anti-inflammatory effects in mice.[Cayman Chemical]
Uses
9-(Palmitoyloxy)octadecanoic acid or 9-PAHSA might be used as a standard to confirm the quantification of fatty acid esters of hydroxy fatty acids (FAHFAs) by liquid chromatography–mass spectrometry (LC-MS). It has also been used to study its effect on apoptosis.
Definition
ChEBI: 9-PAHSA is a FAHFA (fatty acid ester of a hydroxy fatty acid) obtained by formal condensation of the carboxy group of palmitic acid with the hydroxy group of 9-hydroxyoctadecanoic acid (9-hydroxystearic acid). It has a role as a human metabolite, a hypoglycemic agent and an anti-inflammatory agent. It is a FAHFA and a long-chain fatty acid. It is functionally related to a hexadecanoic acid and an octadecanoic acid. It is a conjugate acid of a 9-PAHSA(1-).
General Description
9-(Palmitoyloxy)octadecanoic acid (9-PAHSA) is a palmitic acid ester of 9-hydroxystearic acid.
Biochem/physiol Actions
Palmitic acid and hydroxystearic acid (PAHSA) levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through G-protein-coupled receptor 120 (GPR120) to enhance insulin-stimulated glucose uptake. PAHSAs are fatty acid esters of hydroxy fatty acids (FAHFAs), which are endogenous lipids with the potential to treat diabetes and inflammation.
9-PAHSA Preparation Products And Raw materials
Raw materials
Preparation Products
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