ARM1

Product Name: ARM1
CAS No.: 68729-05-5
Chemical Name: ARM1
Synonyms: ARM1;ARM-1 (ARM1);4-(4-Benzylphenyl)-1,3-thiazol-2-amine;2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-;Epoxide Hydrolase,ARM1,HCT-116 cells,Inhibitor,LTA4H,ARM-1,cytotoxic,positive control,Aminopeptidase,4BSA,inhibit,ARM 1
CBNumber: CB03152553
Molecular Formula: C16H14N2S
Formula Weight: 266.36
MOL File: 68729-05-5.mol

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ARM1 Property

storage temp.: Store at -20°C
solubility: ≤1mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15865
Product name: ARM1
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 15865
Product name: ARM1
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 15865
Product name: ARM1
Purity: ≥95%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 15865
Product name: ARM1
Purity: ≥95%
Packaging: 100mg
Price: $834
Updated: 2024/03/01

Matrix Scientific

Product number: 135662
Product name: 4-(4-Benzylphenyl)-1,3-thiazol-2-amine
Purity: 95%+
Packaging: 2.500g
Price: $1266
Updated: 2021/12/16

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ARM1 Chemical Properties,Usage,Production

Description

Leukotriene A₄ (LTA₄) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB₄ from LTA₄ and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB₄ synthesis in human neutrophils (IC₅₀ = ~0.5 μM) and conversion of LTA₄ to LTB₄ by purified LTA₄ hydrolase (K_i = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA₄ hydrolase.

Uses

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.[Cayman Chemical]

References

[1]. stsiapanava a, olsson u, wan m, et al. binding of pro-gly-pro at the active site of leukotriene a4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. proc natl acad sci u s a. 2014 mar 18;111(11):4227-32.
[2]. haeggstrm jz. leukotriene a4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene b4 biosynthesis. j biol chem. 2004 dec 3;279(49):50639-42.
[3]. snelgrove rj, jackson pl, hardison mt, et al. a critical role for lta4h in limiting chronic pulmonary neutrophilic inflammation. science. 2010 oct 1;330(6000):90-4.

ARM1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARM1 Suppliers

China 25 United States 5 Global 30

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68729-05-5, ARM1Related Search:

ARM1

4-(4-Benzylphenyl)-1,3-thiazol-2-amine

ARM-1 (ARM1)

2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-

Epoxide Hydrolase,ARM1,HCT-116 cells,Inhibitor,LTA4H,ARM-1,cytotoxic,positive control,Aminopeptidase,4BSA,inhibit,ARM 1

68729-05-5