Fluphenazine-N-2-chloroethane (hydrochloride)
- Product Name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- CAS No.
- 3892-78-2
- Chemical Name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- Synonyms
- 10-[3-[4-(2-chloroethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)-10H-phenothiazinedihydrochloride
- CBNumber
- CB03152614
- Molecular Formula
- C22H26Cl2F3N3S
- Formula Weight
- 492.4281496
- MOL File
- 3892-78-2.mol
Fluphenazine-N-2-chloroethane (hydrochloride) Property
- Melting point:
- 224-225 °C
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 18427
- Product name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18427
- Product name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 18427
- Product name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 18427
- Product name
- Fluphenazine-N-2-chloroethane (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $184
- Updated
- 2024/03/01
Fluphenazine-N-2-chloroethane (hydrochloride) Chemical Properties,Usage,Production
Description
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis.
Uses
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane (hydrochloride) is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis.[Cayman Chemical]
Fluphenazine-N-2-chloroethane (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Fluphenazine-N-2-chloroethane (hydrochloride) Suppliers
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11974
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19699
- Advantage
- 58