ChemicalBook > CAS DataBase List > NI-57

NI-57

Product Name: NI-57
CAS No.: 1883548-89-7
Chemical Name: NI-57
Synonyms: CS-2795;NI57;NI 57;BRPF inhibitor NI57;NI-57, 10 mM in DMSO;Inhibitor,inhibit,NI 57,NI-57,NI57,Epigenetic Reader Domain;4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-
CBNumber: CB03156586
Molecular Formula: C19H17N3O4S
Formula Weight: 383.42
MOL File: 1883548-89-7.mol

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NI-57 Property

Boiling point:: 580.1±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤25mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 7.89±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1486
Product name: NI-57
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $111
Updated: 2025/07/31

Cayman Chemical

Product number: 17662
Product name: NI-57
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17662
Product name: NI-57
Packaging: 50mg
Price: $836
Updated: 2024/03/01

Cayman Chemical

Product number: 17662
Product name: NI-57
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17662
Product name: NI-57
Packaging: 10mg
Price: $199
Updated: 2024/03/01

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NI-57 Chemical Properties,Usage,Production

Description

The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system. NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with K_d values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRPFs over other bromodomains. NI-57 shows accelerated FRAP recovery at 1 μM in the BRPF2 FRAP assay, preventing binding of full-length BRPF2 to chromatin. See the Structural Genomics Consortium (SGC) website for more information.

Uses

in vivo

NI-57 has favorable oral bioavailability in mice^[1].

storage

Store at -20°C

References

[1]. http://www.thesgc.org/chemical-probes/ni-57
[2]. klein bj, lalonde me, cté j, et al. crosstalk between epigenetic readers regulates the moz/morf hat complexes. epigenetics. 2014 feb;9(2):186-93.
[3]. ullah m, pelletier n, xiao l, et al. molecular architecture of quartet moz/morf histone acetyltransferase complexes. mol cell biol. 2008 nov;28(22):6828-43.

NI-57 Preparation Products And Raw materials

Raw materials

Preparation Products

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1883548-89-7, NI-57Related Search:

BRPF inhibitor NI57

CS-2795

NI57;NI 57

Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-

Inhibitor,inhibit,NI 57,NI-57,NI57,Epigenetic Reader Domain

4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide

NI-57, 10 mM in DMSO

1883548-89-7