ChemicalBook > CAS DataBase List > Imrecoxib
Imrecoxib
- Product Name
- Imrecoxib
- CAS No.
- 395683-14-4
- Chemical Name
- Imrecoxib
- Synonyms
- 2H-Pyrrol-2-one, 1,5-dihydro-3-(4-methylphenyl)-4-[4-(methylsulfonyl)phenyl]-1-propyl-;Imrecoxib;Imrecoxib USP/EP/BP;Imrecoxib, 10 mM in DMSO;BAP 909,Cyclooxygenase,Inhibitor,COX,Imrecoxib,inhibit,BAP909
- CBNumber
- CB03159916
- Molecular Formula
- C21H23NO3S
- Formula Weight
- 369.48
- MOL File
- 395683-14-4.mol
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Imrecoxib Property
- Boiling point:
- 604.1±55.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (270.65 mM)
- form
- Solid
- pka
- -2.25±0.60(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 395683-14-4
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0079499
- Product name
- Imrecoxib
- Purity
- 99.38%
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
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Imrecoxib Chemical Properties,Usage,Production
Clinical Use
Imrecoxib, a new non-steroid anti-inflammtory drug (NSAID), was launched in China with the trade name of Hengyang® for the treatment of osteoarthritis in 2012. It was originally designed and synthesized by Guo and co-workers at the Institute of Materia Medica (IMM) of the Chinese Academy of Medical Sciences in collaboration with Hengrui Pharmaceuticals. Imrecoxib, which is a moderately selective COX-2 inhibitor (with IC50 values against COX-1 and COX-2 being 115 ± 28 nM and 18 4 nM, respectively).
Synthesis
Imrecoxib has had two synthetic routes reported across several publications. The most likely process-scale route to this drug is described in the scheme, which began with 2-bromo-4'-(methylsulfonyl)-acetophenone (84) and p-tolylacetic acid (85) as starting materials. In the presence of base, |á-bromoketone 84 was treated with acid 85 which resulted in lactone 86 in 72% yield across the two-step sequence. Exposure of lactone 86 with propylamine triggered a ring-opening-ring closing reaction, which resulted in imrecoxib (XIII) directly in 85% yield.
Imrecoxib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imrecoxib manufacturers
Dideu Industries Group Limited
- Product
- Imrecoxib 395683-14-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-16
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