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Pyrotinib Maleate

Product Name
Pyrotinib Maleate
CAS No.
1397922-61-0
Chemical Name
Pyrotinib Maleate
Synonyms
SHR1258 maleate;SHR-1258 maleate;Pyrotinib Maleate;SHR-1258 dimaleate;Pyrotinib dimaleate;SHR-1258 MALEATE;SHR1258 MALEATE;Pyrotinib dimaleate, 10 mM in DMSO;Pyrotinib maleate (SHR-1258 maleate;Epidermal growth factor receptor,inhibit,Inhibitor,Pyrotinib dimaleate,HER1,EGFR,ErbB-1;(R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide dimaleate
CBNumber
CB03159961
Molecular Formula
C40H39ClN6O11
Formula Weight
815.22426
MOL File
1397922-61-0.mol
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Pyrotinib Maleate Property

storage temp. 
Store at -20°C
solubility 
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml
form 
Solid
color 
Light yellow to yellow
Water Solubility 
Water : ≥ 106 mg/mL (130.03 mM)
InChIKey
KLHFGQSCVQPTIN-XUZAKNADSA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0046033
Product name
Pyrotinibdimaleate
Purity
99.63%
Packaging
1mg
Price
$228
Updated
2021/12/16
ChemScene
Product number
CS-0046033
Product name
Pyrotinibdimaleate
Purity
99.63%
Packaging
5mg
Price
$780
Updated
2021/12/16
ChemScene
Product number
CS-0046033
Product name
Pyrotinibdimaleate
Purity
99.63%
Packaging
10mg
Price
$1140
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611569
Product name
Pyrotinib maleate
Packaging
100mg
Price
$1654.1
Updated
2021/12/16
ChemScene
Product number
CS-0046033
Product name
Pyrotinibdimaleate
Purity
99.63%
Packaging
25mg
Price
$2340
Updated
2021/12/16
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Pyrotinib Maleate Chemical Properties,Usage,Production

Uses

Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively[1].

in vivo

Pyrotinib dimaleate has acceptable bioavailability of 20.6%, 43.5% and 13.5% in nude mice, rats and dogs, respectively. Pyrotinib dimaleate has favorable drug-like physicochemical properties and shows relatively higher oral exposure in human subjects (oral; t1/2=15 h) with a much longer half life than that of preclinical animal species such as mouse (i.v.; t1/2=1.56 h; i.g.; t1/2=2.52 h) and rat (i.v.; t1/2=4.42 h; i.g.; t1/2=3.38 h)[1].

IC 50

HER2: 38 nM (IC50); EGFR: 13 nM (IC50)

References

[1] Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X. DOI:10.1016/j.ejps.2017.01.021

Pyrotinib Maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrotinib Maleate Suppliers

China 42 United States 3 Global 45
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1604
Advantage
59
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9856
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
0751-18902340975/189023400307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9227
Advantage
58

1397922-61-0, Pyrotinib MaleateRelated Search:


  • Pyrotinib Maleate
  • 2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)-, (2Z)-2-butenedioate (1:2)
  • Pyrotinib dimaleate
  • SHR1258 maleate
  • SHR-1258 maleate
  • SHR-1258 MALEATE;SHR1258 MALEATE
  • SHR-1258 dimaleate
  • Epidermal growth factor receptor,inhibit,Inhibitor,Pyrotinib dimaleate,HER1,EGFR,ErbB-1
  • (R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide dimaleate
  • Pyrotinib dimaleate, 10 mM in DMSO
  • Pyrotinib maleate (SHR-1258 maleate
  • 1397922-61-0