9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Product Name: 9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one
CAS No.: 851107-28-3
Chemical Name: 9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one
Synonyms: CMP8;CMP 8;CMP-8;CMP8, 10 mM in DMSO;CMP8,inhibit,CMP 8,Estrogen Receptor/ERR,Inhibitor,CMP-8;9a-(4-Chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-9,9a-dihydro-1H-fluoren-3(2H)-one;9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one;9a-[(4-chlorophenyl)methyl]-7-hydroxy-4-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-2,3,9,9a-tetrahydro-1H-fluoren-3-one;3H-Fluoren-3-one, 9a-[(4-chlorophenyl)methyl]-1,2,9,9a-tetrahydro-7-hydroxy-4-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
CBNumber: CB03162778
Molecular Formula: C33H34ClNO3
Formula Weight: 528.08
MOL File: 851107-28-3.mol

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9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one Property

Boiling point:: 703.5±60.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
solubility: DMSO: Soluble
pka: 9.46±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one Chemical Properties,Usage,Production

Uses

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively[1][2].

in vivo

CMP8 (Compound 20h) is dosed in male Balb-c mice (4 mg/kg, ip). The plasma concentration after 4 h is 1.5-fold its EC₅₀ in mammalian cells with a C_max of 0.5 μM after 30 min^[1]^[2].

IC 50

MGERα: 29 nM (IC₅₀); MGRERα: 41 nM (IC₅₀); hERα: 1100 nM (IC₅₀); hERβ: 2200 nM (IC₅₀)

References

[1] Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7;134(9):3942-5. DOI:10.1021/ja209933r
[2] Kinzel O, et al. A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. J Med Chem. 2006 Sep 7;49(18):5404-7. DOI:10.1021/jm060516e
[3] PAOLA GALLINARI. A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.[J]. Chemistry & biology, 2005, 12 8: 883-893. DOI: 10.1016/j.chembiol.2005.05.018

9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one manufacturers

Career Henan Chemical Co

Product: :9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one 851107-28-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%HPLC
Supply Ability: 100KG
Release date: 2020-02-05

851107-28-3, 9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-oneRelated Search:

9a-(4-chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one

CMP8

CMP 8;CMP-8

9a-(4-Chlorobenzyl)-7-hydroxy-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-9,9a-dihydro-1H-fluoren-3(2H)-one

3H-Fluoren-3-one, 9a-[(4-chlorophenyl)methyl]-1,2,9,9a-tetrahydro-7-hydroxy-4-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

CMP8,inhibit,CMP 8,Estrogen Receptor/ERR,Inhibitor,CMP-8

9a-[(4-chlorophenyl)methyl]-7-hydroxy-4-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-2,3,9,9a-tetrahydro-1H-fluoren-3-one

CMP8, 10 mM in DMSO

851107-28-3

C33H34ClNO3