Aminooxy-PEG5-azide
- Product Name
- Aminooxy-PEG5-azide
- CAS No.
- 1919045-02-5
- Chemical Name
- Aminooxy-PEG5-azide
- Synonyms
- Aminooxy-PEG5-azide;((17-azido-3,6,9,12,15-pentaoxaheptadecyl)oxy)-l4-azane;O-(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)hydroxylamine
- CBNumber
- CB03162839
- Molecular Formula
- C12H26N4O6
- Formula Weight
- 322.35804
- MOL File
- 1919045-02-5.mol
Aminooxy-PEG5-azide Property
- storage temp.
- 2-8°C, sealed storage, away from moisture
- solubility
- DMSO : 100 mg/mL (310.21 mM; Need ultrasonic)
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- BP-23194
- Product name
- Aminooxy-PEG5-azide
- Purity
- 95%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
Aminooxy-PEG5-azide Chemical Properties,Usage,Production
Description
Aminooxy-PEG5-azide is a biolabeling reagent comprising an aminooxy group and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. by reacting with an aldehyde moiety to form an oxime bond, if a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Aminooxy-PEG5-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG5-azide manufacturers
- Product
- Aminooxy-PEG5-azide 1919045-02-5
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-22