ChemicalBook > CAS DataBase List > S1p receptor agonist 1

S1p receptor agonist 1

Product Name: S1p receptor agonist 1
CAS No.: 1514888-56-2
Chemical Name: S1p receptor agonist 1
Synonyms: CS-2465;YUN88562;icanbelimod;S1P-agonist-1;S1p receptor agonist 1;S1p receptor agonist 1, 10 mM in DMSO;1-(2-fluoro-4-(5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;1-{2-fluoro-4-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-benzyl}-3-azetidine carboxylic acid;1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid;3-Azetidinecarboxylic acid, 1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
CBNumber: CB03164873
Molecular Formula: C23H24FN3O3
Formula Weight: 409.45
MOL File: 1514888-56-2.mol

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S1p receptor agonist 1 Property

Boiling point:: 566.3±60.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6.8 mg/mL (16.61 mM)
form: Solid
pka: 2?+-.0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6254
Product name: S1preceptoragonist1
Purity: 99.97%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6254
Product name: S1preceptoragonist1
Purity: 99.97%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6254
Product name: S1preceptoragonist1
Purity: 99.97%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-6254
Product name: S1preceptoragonist1
Purity: 99.97%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-6254
Product name: S1preceptoragonist1
Purity: 99.97%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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S1p receptor agonist 1 Chemical Properties,Usage,Production

Uses

Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.

in vivo

Icanbelimod (oral administration; 0.01 mg/kg-1 mg/kg) at all dose is active, and only a dose of 0.01 mg/kg is required to observe a decrease in the number of peripheral blood lymphocytes by more than 50% and a decrease in the 1 mg/kg dose. Besides, this compound is lymphocyte-specific, which dose not significantly alter the number of peripheral monocytes and other white blood cells in SD rats^[1].Icanbelimod (oral administration; 3 mg/kg; 12 days) is has been proved to block lymphocyte efflux. In the development of type II collagen-induced arthritis in rat model, compound 2 is effective in inhibiting the development of joint swelling in arthritis and joint structure destruction^[1].Icanbelimod (oral administration; 0.3-1mg/kg; 30 days; once daily) inhibits the development of experimental autoimmune encephalitis (EAE) as a dose-dependent manner in mice model^[1].

Animal Model:	Lewis rats^[1]
Dosage:	3 mg/kg
Administration:	Oral administration
Result:	Decreased the severity score of arthritis in the four-legged rats.

Animal Model:	Female C57BL/6 mice^[1]
Dosage:	0.03, 0.1, and 1 mg/kg
Administration:	Oral administration
Result:	Decreased the severity score of EAE in MOG 35-55?induced mice.

References

[1] Zhenwei, et al. Immune adjustment compound, use thereof and pharmaceutical composition comprising same. Patent WO2015039587A1

S1p receptor agonist 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1514888-56-2, S1p receptor agonist 1Related Search:

S1p receptor agonist 1

1-(2-fluoro-4-(5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid

CS-2465

S1P-agonist-1

YUN88562

3-Azetidinecarboxylic acid, 1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-

icanbelimod

S1p receptor agonist 1,arthritis,Lysophospholipid Receptor,autoimmune,EAE,S-1p receptor agonist 1,sclerosis,encephalitis,Multiple,inhibit,Inhibitor,LPL Receptor

1-{2-fluoro-4-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-benzyl}-3-azetidine carboxylic acid

S1p receptor agonist 1, 10 mM in DMSO

1514888-56-2