DDP-38003 (dihydrochloride)
- Product Name
- DDP-38003 (dihydrochloride)
- CAS No.
- 1831167-98-6
- Chemical Name
- DDP-38003 (dihydrochloride)
- Synonyms
- DDP38003;DDP-38003 2HCl;DDP-38003 (dihydrochloride);DDP-38003 dihydrochloride, 10 mM in DMSO;DDP 38003 DIHYDROCHLORIDE; DDP38003 DIHYDROCHLORIDE;N-{4-[(1S,2R)-2-Aminocyclopropyl]phenyl}-4-(4-methyl-1-piperazinyl)benzamide dihydrochloride;Benzamide,N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-,hydrochloride(1:2)
- CBNumber
- CB03167607
- Molecular Formula
- C21H27ClN4O
- Formula Weight
- 386.92
- MOL File
- 1831167-98-6.mol
DDP-38003 (dihydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 29 mg/mL (68.50 mM)
- form
- Solid
- color
- Brown to reddish brown
N-Bromosuccinimide Price
- Product number
- DC10413
- Product name
- DDP-38003dihydrochloride
- Purity
- >98%
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- DC10413
- Product name
- DDP-38003dihydrochloride
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
DDP-38003 (dihydrochloride) Chemical Properties,Usage,Production
Description
DDP-38003 2HCl is an orally available inhibitor of histone lysine-specific demethylase 1A (LSD1).
Uses
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM[1].
in vivo
DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].
IC 50
KDM1/LSD1
References
[1] Vianello P, et al. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem. 2016 Feb 25;59(4):1501-17. DOI:10.1021/acs.jmedchem.5b01209
DDP-38003 (dihydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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