ChemicalBook > CAS DataBase List > Olcegepant (hydrochloride)
Olcegepant (hydrochloride)
- Product Name
- Olcegepant (hydrochloride)
- CAS No.
- 586368-06-1
- Chemical Name
- Olcegepant (hydrochloride)
- Synonyms
- BIBN-4096 hydrochloride;BIBN4096BS hydrochloride;BIBN-4096BS hydrochloride;BIBN 4096BS hydrochloride;Olcegepant (hydrochloride);BIBN-4096 HYDROCHLORIDE; BIBN-4096BS HYDROCHLORIDE; BIBN4096BS HYDROCHLORIDE; BIBN 4096BS HYDROCHLORIDE
- CBNumber
- CB03167627
- Molecular Formula
- C38H48Br2ClN9O5
- Formula Weight
- 906.12
- MOL File
- 586368-06-1.mol
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Olcegepant (hydrochloride) Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- Light yellow to yellow
- Water Solubility
- Water: ≥ 66.66 mg/mL (73.57 mM)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6321
- Product name
- Olcegepant(hydrochloride)
- Purity
- 99.31%
- Packaging
- 5mg
- Price
- $192
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6321
- Product name
- Olcegepant(hydrochloride)
- Purity
- 99.31%
- Packaging
- 10mg
- Price
- $324
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6321
- Product name
- Olcegepant(hydrochloride)
- Purity
- 99.31%
- Packaging
- 50mg
- Price
- $1355
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573103
- Product name
- Olcegepant hydrochloride
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1356.6
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573103
- Product name
- Olcegepant hydrochloride
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2691.1
- Updated
- 2021/12/16
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Olcegepant (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective calcitonin gene-related peptide (CGRP) antagonist with a Ki value of 14.4 pM for human CGRP.
in vivo
Olcegepant (BIBN4096BS) in doses between 1 and 30 μg/kg (i.v.) inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys. Pre-treatment with Olcegepant (900 μg/kg) inhibits the capsaicin-induced expression of Fos throughout the spinal trigeminal nucleus by 57%.
target
IC50: 0.03 nM (CGRP1)
Ki: 14.4 pM (hCGRP)
Olcegepant (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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